Proteases have a 60 percent market share in the global enzyme market, owing to their wide range of applications in detergent, leather, pharmaceuticals, and food. Serine protease is the most popular commercial protease, accounting for 89 percent of all commercial proteases sold each year. Serine Proteases are chymotrypsin-like proteases with a serine group in their active site that aid in the binding and cleavage of substrates. Serine proteases have a broad substrate selectivity and activity that extends beyond peptidase, making them useful in a variety of sectors. The demand for serine protease varies widely over the world, depending on industrial development.