The global extramammary Paget disease (EMPD) market is shaped by the disease's rarity and complexity, presenting unique challenges and opportunities. EMPD primarily affects areas such as the vulva, perianal region, and axilla, often manifesting as pruritic or eczematous lesions, which can lead to misdiagnosis. The limited patient population impacts the commercial viability of developing new therapies, necessitating targeted research and innovative treatment approaches. Diagnostic methods, including biopsy and immunohistochemistry, are crucial for accurate identification, while treatment options range from surgical excision to topical therapies and systemic medications. The market is also influenced by the growing awareness of EMPD among healthcare professionals, leading to earlier diagnosis and intervention, thus driving demand for effective therapies. Furthermore, advancements in biomarker research and personalized medicine hold promise for enhancing treatment outcomes. The involvement of specialized clinics, hospitals, and home care services underscores the multifaceted nature of care delivery in this niche market. As awareness and research continue to evolve, the EMPD market is poised for growth, presenting opportunities for stakeholders engaged in the development of targeted diagnostic and therapeutic solutions.