Global Rolling Circle Amplification Market – Industry Trends and Forecast to 2030

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Rolling Circle Amplification Market Analysis and Size

Environmental contaminants are a global concern, and developing a rapid, on-site, and cost-effective monitoring method is an effective remediation strategy. However, this remains difficult, particularly when it comes to detecting various contaminants in complex water environments. For instance, the use of molecular methods has recently gained popularity, rolling circle amplification (RCA) is an isothermal enzymatic process that uses a circular template and special nucleic acid polymerases to amplify a short nucleic acid primer to form a long single-stranded nucleic acid. This approach can also be developed into a device for point-of-need monitoring of environmental pollutants.

Data Bridge Market Research analyses that the rolling circle amplification market which was USD 834.75 million in 2022, is expected to reach USD 1965.70 million by 2030, at a CAGR of 11.3% during the forecast period 2023 to 2030. In addition to the insights on market scenarios such as market value, growth rate, segmentation, geographical coverage, and major players, the market reports curated by the Data Bridge Market Research also include depth expert analysis, patient epidemiology, pipeline analysis, pricing analysis, and regulatory framework.

Rolling Circle Amplification Market Scope and Segmentation  

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Market Definition

Rolling circle amplification (RCA) is an isothermal enzymatic process that uses a circular DNA template and special DNA or RNA polymerases to amplify a short DNA or RNA primer to form a long single stranded DNA or RNA. The RCA product is a concatemer composed of tens to hundreds of tandem repeats that complement the circular template. The DNA amplification technique's power, simplicity, and versatility have made it an appealing tool for biomedical research and nanobiotechnology. RCA has traditionally been used to create sensitive diagnostic methods for a wide range of targets such as nucleic acids (DNA, RNA), small molecules, proteins, and cells. RCA has also received a great deal of attention in the fields of nanotechnology and nanobiotechnology.

Rolling Circle Amplification Market Dynamics

Drivers

• Improve the accuracy of in-situ analysis

In commonly used RCA-based methods, rolling circle amplification (RCA) is used to generate distinct fluorescent signals in situ by relying on the self-collapsing properties of single-stranded DNA. The reduced size of RCPs increases the local concentration of fluorophores, increasing signal intensity and signal-to-noise ratio. Furthermore, we discovered that RCPs sometimes disintegrate and are recorded as multiple RCPs, which our cross-hybridizing DNA oligonucleotide prevents. These effects of RCP compaction improve the accuracy of both visual and automated in situ analysis for RCA-based methods such as proximity ligation assays (PLA) and padlock probes.

• Rising applications of rolling circle amplification

Immuno-RCA employs an antibody conjugated to an oligonucleotide to detect a single protein. A circular DNA template can be hybridized to this and then amplified by the enzyme phi29 polymerase with the antibody-conjugated oligonucleotide as a primer. This will result in the formation of an RCP that is covalently linked to the antibody. Two antibodies are conjugated with two different oligonucleotides in PLA (proximity probes). Suppose the proximity probes bind to their targets in close proximity. In that case, they will act as a hybridization/ligation template for two more oligonucleotides, resulting in the formation of a circular DNA template that can be amplified using one of the proximity probes as a primer for RCA.

Opportunities

• Increasing with the advancement of science and technology

Rolling circle amplification has been steadily increasing with the advancement of science and technology, which is expected to significantly impact cell rolling circle amplification during the forecast period of 2023 to 2030. Some of the factors that will drive the growth of the rolling circle amplification market include increased use to study and develop sensitive detection methods, which will allow for more efficient treatment and a higher survival rate for cancer patients, as well as advancements in the use of the RCA technique for biomedical applications and medical biosensors.

Restraints/Challenges

• High cost associated with synthesis

There are still some errors in the RCA method's development, the padlock probe is frequently close to 100 bp, the synthesis cost is relatively high. Also there is a problem with background interference during signal detection.

This rolling circle amplification market report provides details of new recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on the rolling circle amplification market contact Data Bridge Market Research for an Analyst Brief, our team will help you take an informed market decision to achieve market growth.

Global Rolling Circle Amplification Market Scope

The rolling circle amplification market is segmented on the basis of type, usage, application and end-user. The growth amongst these segments will help you analyze meagre growth segments in the industries and provide the users with a valuable market overview and market insights to help them make strategic decisions for identifying core market applications.

Type

• Enzyme-Aided RCA Biosensor
• AuNP-RCA Biosensor
• Aptamer Biosensor
• Micromolecular Biosensor
• Transcription Factor (TF) Biosensor
• MiRNAs Biosensor
• Protein Biosensor
• Other

 Usage

• Molecular Biology
• Materials Science
• Medicine

 Application

• Diagnosis
• Genomics
• Proteomics
• Biosensing
• Drug Discovery
• Nanotechnology

 End-User

• Hospitals
• Research Institutions
• Others

Rolling Circle Amplification Market Regional Analysis/Insights

The rolling circle amplification market is analyzed and market size insights and trends are provided by country, type, usage, application and end-user as referenced above.

The countries covered in the rolling circle amplification market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

North America dominates the rolling circle amplification market due to the high investments in healthcare infrastructures, availability of government funds, technological advancements and rising research in the fields of genetic testing.

Asia-Pacific is expected to grow at the highest growth rate in the forecast period of 2023 to 2030 due to the favourable government initiative for the development of healthcare infrastructure and rising economies such as India and China.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points like down-stream and upstream value chain analysis, technical trends and porter's five forces analysis, case studies are some of the pointers used to forecast the market scenario for individual countries. Also, the presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.

Healthcare Infrastructure Growth Installed base and New Technology Penetration

The rolling circle amplification market also provides you with detailed market analysis for every country growth in healthcare expenditure for capital equipment, installed base of different kind of products for rolling circle amplification market, impact of technology using life line curves and changes in healthcare regulatory scenarios and their impact on the rolling circle amplification market. The data is available for historic period 2011-2021.

Competitive Landscape and Rolling Circle Amplification Market Share Analysis

The rolling circle amplification market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies' focus related to rolling circle amplification market.

Some of the major players operating in the rolling circle amplification market are:

• Thermo Fisher Scientific Inc. (U.S.)
• Abbott (U.S.)
• QIAGEN (Germany)
• Agilent Technologies Inc. (U.S.)
• Bayer AG (Germany)
• BD (U.S.)
• F. Hoffmann-La Roche Ltd (Switzerland)
• BIOMÉRIEUX (France)
• Bio-Rad Laboratories Inc. (U.S.)
• Takara Bio, Inc. (Japan)

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