全球多形性胶质母细胞瘤治疗市场 - 行业趋势和 2029 年预测

市场分析和见解

多形性胶质母细胞瘤(GBM) 是具有星形细胞分化的 WHO IV 级恶性肿瘤。作为临床诊断最常见的中枢神经系统 (CNS) 肿瘤之一，关于此类肿瘤的描述和观点演变的历史报道多种多样。最早有记录的胶质瘤报告出现在英国科学报告中，Berns 于 1800 年发表，Abernety 于 1804 年发表，Rudolf Virchow 于 1865 年首次给出了全面的组织形态学描述。1926 年，Percival Bailey 和 Harvey Cushing 为现代胶质瘤分类奠定了基础。1934 年至 1941 年间，胶质瘤研究领域最卓有成效的研究人员是 Hans-Joachim Scherer，他提出了 GBM 的一些临床形态学方面假设。随着分子和基因测试的引入，GBM 的真正多形性已经确定，不同的基因型具有相同的组织形态学和 IHC 图像，以及胶质瘤形成的某些方面。GBM 的发展需要 GBM 干细胞中发生特定的触发突变 - 原发性 GBM，或单个突变的缓慢聚集，没有明显的触发突变 - 继发性 GBM。自从 200 多年前首次描述这些恶性肿瘤以来，GBM 的知识与中枢神经系统的一般医学知识密切相关。在这段时间里，随着中枢神经系统和一般医学知识的进步，已经取得了几项重大飞跃。对多形性胶质母细胞瘤治疗的需求正在增加，制造商参与新产品的发布，增加管道产品和市场活动参与。这些决定最终促进了市场的增长。 

The glioblastoma multiforme treatment market report provides details of market share, new developments, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, product approvals, strategic decisions, product launches, geographic expansions, and technological innovations in the market. To understand the analysis and the market scenario contact us for an analyst brief, our team will help you create a revenue impact solution to achieve your desired goal. Strategic initiatives such as collaboration, agreement, and signing  of sales agreements to invent and innovate pharmacological treatments are the major drivers which propelled the demand of the market in the forecast period.

The glioblastoma multiforme treatment market is supportive and aims to reduce the progression of the disease. Data Bridge Market Research analyses that  glioblastoma multiforme treatment market will grow at a CAGR of 8.1% during the forecast period of 2022 to 2029.

Market Definition

Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor and accounts for 60% of brain tumors in adults. GBMs can arise in the brain de novo or evolve from lower-grade astrocytoma. In adults, GBM occurs most often in the cerebral hemispheres, especially in the frontal and temporal lobes of the brain. Many genetic and environmental factors have been studied in glioblastoma multiforme, but no risk factor that accounts for a large proportion of GBM has been identified. So like many other cancers, GBM is sporadic, although some studies indicate a high prevalence (17%) of prior therapeutic irradiation among patients with GBM. The latency between irradiation and the development of GBM varies from a few years to several decades. There is no substantial evidence of GBM association with lifestyle factors like smoking, alcohol consumption, drug use, or exposure to N- Nitroso compounds. Studies have shown that the use of mobile phones doesn't increase the risk of development of GBM; however, its association with long term use needs further confirmation.                               

Global Glioblastoma Multiforme Treatment Market Dynamics

Drivers

• Growing prevalence of glioblastoma multiforme

Glioblastoma multiforme (GBM) is the most commonly occurring malignant primary brain tumor, representing 77%-81% of all central nervous system (CNS) primary malignant tumors. The World Health Organization classified it as a grade IV diffuse astrocytic and oligodendroglial tumor. The mean age of primary GBM presentation is 62 years, and the median survival is approximately 14.6 months. The poor prognosis associated with GBM is well documented, while survival rates remain disappointingly low despite medical and surgical advances. As per the study, International studies reveal an approximate annual incidence rate of 0.59 to 5 per 100,000 persons; however, studies indicate a rise in incidence. Miranda-Filho et al. in 2017 described increasing rates of CNS and brain cancers in countries in South America, Eastern Europe, and Southern Europe, while decreasing rates were only reported in Japan. Dobes et al. in 2011 have also noted an increasing incidence of GBM tumors in two of their multicentered Australian studies, with a particular increase in frontal and temporal lobe GBM tumors. The increased incidence of glioblastoma multiforme raises the demand for early detection and diagnosis via utilizing the latest technology, propelling the global glioblastoma multiforme treatment market. The rising incidence of glioblastoma across the globe is expected to accelerate the demand for glioblastoma multiforme treatment. Thus, the increased incidence rates of glioblastoma multiforme are expected to boost the market's growth.

• Increasing research and development (R&D)

Increasing research and development (R&D) activities in molecular biotechnology and gene therapy for cancer and related diseases have facilitated the development of various biological drugs. These drugs assist in diminishing the side effects of the existing treatment methods, thus creating broader acceptance amongst patients. Tumor heterogeneity and variation in the patient-to-patient treatment approach are expected to increase the demand for a personalized treatment approach to manage glioblastoma  multiforme. The approval of new treatments is expected to increase the life expectancy of patients living with glioblastoma multiforme. Furthermore, a special designation granted to investigational drugs by the FDA is expected to expedite novel therapy's approval process and commercialization. An increase in collaborations between researchers and market players is expected to boost the development of novel and effective treatment options for glioblastoma multiforme. The increasing approval for novel therapy and combination therapy is expected to drive the glioblastoma multiforme treatment market. 

Opportunity

• Increasing drug approvals

The escalating demand for glioblastoma multiforme treatment should yield more regulatory approvals for associated drugs. Increasing regulatory endorsements for related drugs and recombinant products will constitute an increase in glioblastoma multiforme treatment market value in the coming years. In the framework of a Pan American Health Organization (PAHO) initiative to promote the recognition of Drug Regulatory Authorities, ANMAT´s evaluation process finished on December 11, 2009. The glioblastoma multiforme treatment industry has witnessed numerous drug approvals in recent years, driven by the increasing fatality rate of the disease. Increasing drug approvals will ramp up the glioblastoma multiforme treatment market demand.

Restraints/Challenges

High cost of glioblastoma multiforme treatment

The diagnostic tests for glioblastoma multiforme include highly technologically advanced products. Developing those products involves rigorous research and development by the developing player. Thus, the cost of the product remains high, which proportionally increases the cost of testing.

The diagnostic tools and techniques used for the diagnosis of glioblastoma multiforme include

radiation therapy, chemotherapy, among others. Early stages of GBM typically present with minimal or no symptoms; therefore, GBM is frequently diagnosed at advanced stages, resulting in a poor prognosis. Thus, the high cost of treating the glioblastoma multiforme using the advanced modalities and technology products will act as a major restraining factor for the growth of the global glioblastoma multiforme treatment market.

Recent Developments

• In April 2022, Elekta and GE Healthcare announced that they had signed a global commercial collaboration agreement in the field of radiation oncology, enabling them to provide hospitals a comprehensive offering across imaging and treatment for cancer patients requiring radiation therapy. This partnership will allow the companies to jointly promote solutions for each cancer center’s needs
• In July 2019, Amgen and Allergan plc announced that MVASI (bevacizumab-awwb), a biosimilar to Avastin (bevacizumab) is available in the United States (U.S.). This launch will enhance the sales of the product in the region

Glioblastoma Multiforme Treatment Market Scope

The glioblastoma multiforme treatment market is categorized into seven notable segments which are based on type, treatment, patient type, drug type, route of administration, end user and distribution channel. The growth among segments helps you analyse niche pockets of growth and strategies to approach the market and determine your core application areas and the difference in your target markets.

Type

• Primary (De Novo)
• Secondary

On the basis of  type, the glioblastoma multiforme treatment market is segmented into primary (De Novo) and secondary.

Treatment

• Surgery
• Radiotherapy
• Medications

On the basis of treatment, the glioblastoma multiforme treatment market is segmented into surgery, radiotherapy and medications.

Patient Type

• Adult
• Geriatric
• Child

On the basis of patient type, the glioblastoma multiforme treatment market is segmented into adult, geriatric and child.

Drug Type

• Branded
• Generics

On the basis of drug type, the glioblastoma multiforme treatment market is segmented into generics and branded.

Route of Administration

• Oral
• Parenteral
• Others

On the basis of route of administration, the glioblastoma multiforme treatment market is segmented into parenteral, oral and others.

End User

• Hospitals
• Clinics
• Home Healthcare
• Others

On the basis of end user, the glioblastoma multiforme treatment market is segmented into hospitals, clinics, home healthcare and others.

Distribution Channel

• Hospital Pharmacy
• Retail Pharmacy
• Online Pharmacy
• Others

On the basis of distribution channel, the glioblastoma multiforme treatment market is segmented into hospital pharmacy, retail pharmacy and others.

Global Glioblastoma Multiforme Treatment Market Regional Analysis/Insights

The glioblastoma multiforme treatment market is analysed and market size insights and trends are provided by type, treatment, patient type, drug type, route of administration, end user and distribution channel as referenced above.

The regions covered in the glioblastoma multiforme treatment market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina, Peru and Rest of South America as part of South America.

In North America, the U.S. is expected to dominate the market due to the increasing prevalence of the disease in the region. Germany is expected to dominate the European market due to the large number of major market players. Japan is expected to dominate the Asia-Pacific market due to the increased research and development activities in the country.

The country section of the report also provides individual market impacting factors and changes in market regulation that impact the current and future trends of the market. Data points such as down-stream and upstream value chain analysis, technical trends and porter's five forces analysis, case studies are some of the pointers used to forecast the market scenario for individual countries. Also, the presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.   

Competitive Landscape and Glioblastoma Multiforme Treatment Market Share Analysis

The glioblastoma multiforme treatment market competitive landscape provides details by the competitors. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, and application dominance. The above data points provided are only related to the companies' focus on glioblastoma multiforme treatment market.

该市场的一些主要参与者包括 F. Hoffmann-La Roche AG、安进公司 (Amgen Inc.)、默克公司 (Merck & Co., Inc.)、辉瑞公司 (Pfizer Inc.)、瓦里安医疗系统公司 (Varian Medical Systems, Inc.)（西门子医疗的子公司）、蔡司国际 (ZEISS International)、Amneal Pharmaceuticals LLC、Elekta、Sun Pharmaceutical Industries Ltd、Teva Pharmaceutical Industries Ltd.、Eckert & Ziegler、Accord Healthcare、Angiochem、ANI Pharmaceuticals, Inc.、Arbor Pharmaceuticals, LLC.（Azurity Pharmaceuticals, Inc. 的子公司）、阿斯利康 (AstraZeneca)、Cantex Pharmaceuticals, Inc.、CELON LABS、Diffusion Pharmaceuticals Inc.、EnGeneIC、ERC.SA.、Genenta science、Jazz Pharmaceuticals, Inc.、Loxo Oncology（礼来公司的子公司）、诺华公司 (Novartis AG)、VBL THERAPEUTICS、Viatris Inc. 和 Zydus Pharmaceuticals, Inc. 等。

研究方法

数据收集和基准年分析是使用具有大样本量的数据收集模块完成的。使用市场统计和连贯模型分析和估计市场数据。此外，市场份额分析和关键趋势分析是市场报告中的主要成功因素。DBMR 研究团队使用的关键研究方法是数据三角测量，其中包括数据挖掘、数据变量对市场影响的分析以及主要（行业专家）验证。除此之外，数据模型还包括供应商定位网格、市场时间线分析、市场概览和指南、公司定位网格、公司市场份额分析、测量标准、全球与区域和供应商份额分析。如有进一步询问，请要求分析师致电。

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