Отчет об анализе размера, доли и тенденций мирового рынка систем экспрессии эукариот – обзор отрасли и прогноз до 2031 года

Анализ рынка систем эукариотической экспрессии

Рынок эукариотических систем экспрессии быстро расширяется в результате достижений в области биотехнологии и растущего спроса на терапевтические белки. Создание улучшенных линий клеток млекопитающих и дрожжей, которые улучшают выход и функциональность белка, является важным нововведением. Более точные генетические модификации стали возможны благодаря таким технологиям, как CRISPR и синтетическая биология, что приводит к более эффективным системам экспрессии. Кроме того, потребность в индивидуальных системах экспрессии, подходящих для конкретных приложений, обусловлена ​​ростом персонализированной медицины. Поскольку все больше денег тратится на НИОКР для дальнейшего совершенствования этих систем, рынок будет расти, поскольку компании концентрируются на сокращении расходов и упрощении производственных процессов. Учитывая все обстоятельства, рынок эукариотических систем экспрессии быстро растет как из-за требований рынка, так и из-за технологических достижений.

Размер рынка систем эукариотической экспрессии

Объем мирового рынка эукариотических систем экспрессии в 2023 году оценивался в 724,57 млн ​​долларов США, а к 2031 году, по прогнозам, он достигнет 1112,20 млн долларов США, при среднегодовом темпе роста 5,50% в прогнозируемый период с 2024 по 2031 год. Помимо информации о рыночных сценариях, таких как рыночная стоимость, темпы роста, сегментация, географический охват и основные игроки, рыночные отчеты, подготовленные Data Bridge Market Research, также включают в себя углубленный экспертный анализ, эпидемиологию пациентов, анализ разработки, анализ цен и нормативно-правовую базу.

Тенденции рынка эукариотических систем экспрессии

« Растет популярность линий клеток млекопитающих для биофармацевтики»

The market for eukaryotic expression systems is experiencing a notable surge in the use of mammalian cell lines, largely driven by the rising demand for therapeutic biologics and high-quality recombinant proteins. Mammalian systems, particularly Chinese hamster ovary (CHO) and HEK293 cells, provide superior post-translational modifications that are essential for ensuring the efficacy and safety of therapeutic proteins. This capability is increasingly important as the complexity of biologics continues to grow. Furthermore, advancements in gene-editing technologies, such as CRISPR/Cas9, are significantly enhancing the efficiency of producing stable cell lines, making mammalian expression systems even more attractive for biopharmaceutical applications. As companies pivot towards developing more intricate biologics, the reliance on mammalian expression systems is set to increase. This trend is anticipated to drive innovations in cell culture techniques and spur greater investment in associated technologies, creating a robust environment for research and development in the biotechnology sector.

Report Scope and Eukaryotic Expression Systems Market Segmentation         

Eukaryotic Expression Systems Market Definition

Eukaryotic expression systems refer to cellular systems that utilize eukaryotic cells—organisms whose cells have a nucleus—to produce proteins, particularly recombinant proteins and therapeutic biologics. These systems are essential for ensuring proper post-translational modifications, which are critical for the functionality and stability of complex proteins. Common eukaryotic expression systems include yeast, insect, and mammalian cell lines, such as Chinese hamster ovary (CHO) and HEK293 cells. These systems are widely used in biotechnology and pharmaceutical industries for producing proteins that require precise folding, glycosylation, and other modifications that prokaryotic systems like bacteria cannot provide. As a result, eukaryotic expression systems play a crucial role in the development of vaccines, antibodies, and other biologics, making them invaluable in modern medicine and research.

Eukaryotic Expression Systems Market Dynamics

Drivers

• Growth of the E. coli-Based Protein Production

The market is expanding due to the large-scale production of proteins using E. coli bacteria, the most commonly utilized artificial expression host. Its popularity stems from a well-characterized genomic and physiological sequencing system, which simplifies the cloning procedure and enhances the efficiency of recombinant protein production. For instance, E. coli can produce proteins at a rate of several grams per liter, making it cost-effective for industrial applications. Moreover, the ability to engineer promoter regions in E. coli improves transcription efficiency, increasing protein yield. This efficiency is particularly crucial in the pharmaceutical and biotechnology industries, where rapid production of therapeutics is essential. Consequently, these factors are projected to significantly boost market growth in the coming years.

• Increasing Application of Stem Cells

The need for complex proteins is growing due to advancements in stem cell research and tissue engineering, which increases the dependence on eukaryotic expression systems. For instance, the production of induced pluripotent stem cells (iPSCs) requires specialized proteins for growth and differentiation. Therefore, eukaryotic systems such as CHO and HEK293 cells are required to produce high-quality, biologically relevant proteins. For the creation of organs and tissues intended for transplantation and regenerative medicine, these proteins are necessary. In addition, the market for tissue engineering is expanding quickly as a result of the growing need for growth factors and scaffolds.

Opportunities

• Optimizing Protein Production with Synthetic Biology

The integration of synthetic biology with eukaryotic expression systems presents a significant market opportunity by enabling the engineering of new cell lines that enhance the productivity of complex protein production. By precisely manipulating genetic elements, researchers can develop cell lines optimized for specific production goals. For example, utilizing synthetic promoters and ribosome-binding sites allows for fine-tuning gene expression in CHO or HEK293 cells, ultimately increasing yields of therapeutic proteins. In addition, the incorporation of synthetic pathways can improve glycosylation patterns, enhancing the stability and functionality of these proteins. This innovative approach not only accelerates the development of biopharmaceuticals but also reduces production costs, making it a crucial advancement in the field. As biopharmaceutical companies increasingly adopt these methodologies, the market is expected to expand, fostering further innovations in protein production and therapeutic development.

•  Eukaryotic Expression Systems in Biosimilars Production

The market for therapeutic biologics that closely resemble approved products, or biosimilars, is expanding, and this presents eukaryotic expression systems with considerable opportunities to produce these less expensive alternatives. The market for biosimilars is expected to expand quickly as original biologics lose their patent protection, since patients and healthcare providers are beginning to recognize them more and more for their affordability. For the production of biosimilars, eukaryotic systems—in particular, CHO and HEK293 cell lines—are essential because they enable the post-translational modifications required to guarantee safety and efficacy. Manufacturers can now meet the growing demand for biosimilars thanks to recent developments in bioprocessing technologies, which enable faster development cycles and higher yields. This trend enhances accessibility to essential therapies and drives innovation within the biopharmaceutical industry.

Restraints/Challenges

• High Production Cost

Smaller biotech companies, eukaryotic expression systems—particularly mammalian cell lines—can be unaffordably costly to maintain and run. The financial load is increased by the expenses related to sophisticated culture media, bioreactor systems, and strict environmental regulations. For instance, maintaining ideal growth conditions for HEK293 or CHO cells necessitates highly qualified staff and sophisticated infrastructure, which raises operating costs. Moreover, it can take months or even years to develop stable cell lines, which raises costs even more. This financial barrier may impede innovation in biopharmaceutical development by preventing smaller companies from accessing state-of-the-art expression technologies. Because of this, many startups might find it difficult to compete with larger companies that can afford to purchase these advanced systems.

• Technological Limitations

Certain complex proteins are difficult for current eukaryotic expression systems to produce, particularly those that need particular post-translational modifications (PTMs) to function properly. For instance, complex glycosylation patterns in proteins—like therapeutic antibodies—may prevent them from achieving the required structural integrity in conventional mammalian systems. Glycosylation variations between animal and human cell lines can lead to increased immunogenicity and changed efficacy, which reduces the therapeutic potential of these proteins. Furthermore, it might not be possible to produce enough proteins that need special phosphorylation or lipidation modifications, which would restrict their application in targeted therapies. The challenge of accurately replicating the entire range of human PTMs limits the suitability of eukaryotic systems for the creation of specific sophisticated biologics, thereby affecting their overall commercial viability.

This market report provides details of new recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on the market contact Data Bridge Market Research for an Analyst Brief, our team will help you take an informed market decision to achieve market growth.

Eukaryotic Expression Systems Market Scope

The market is segmented on the basis of type, host type, and application. The growth amongst these segments will help you analyse meagre growth segments in the industries and provide the users with a valuable market overview and market insights to help them make strategic decisions for identifying core market applications.

Type

• MEL
• COS
• CHO
• Insect cells
• Reagents
• Expression Vectors
• Competent Cells

Host Type

• S. cerevisiae
• Filamentous Fungi
• Leishmania
• Baculovirus-Infected Cells

Application

• Bacterial Expression System
• Yeast Expression System
• Insect Expression System
• Mammalian Expression System

Eukaryotic Expression Systems Market Regional Analysis

The market is analysed and market size insights and trends are provided by country, type, host type, and application as referenced above.

The countries covered in the market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

North America dominates the eukaryotic expression systems market, driven by continuous advancements in genome sequencing and significant innovations in proteomics, particularly in the United States and Canada. This region benefits from a robust research infrastructure, enabling cutting-edge developments in biotechnology and pharmaceutical applications. In addition, strong investments in research and development by both public and private sectors further enhance the capabilities of eukaryotic expression systems, positioning North America as a leader in the global market.

The Asia-Pacific region is set to become a leading force in the eukaryotic expression systems market from 2022 to 2029, driven by a surge in research studies conducted by market participants. Increased investment in research and development activities is further propelling this growth, as companies seek to innovate and enhance their capabilities. In addition, the rising awareness of biotechnology and the growing demand for therapeutic biologics in this region are expected to contribute significantly to market expansion during the forecast period.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as down-stream and upstream value chain analysis, technical trends and porter's five forces analysis, case studies are some of the pointers used to forecast the market scenario for individual countries. Also, the presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.  

Eukaryotic Expression Systems Market Share

Конкурентная среда рынка содержит сведения о конкурентах. Включены сведения о компании, ее финансах, полученном доходе, рыночном потенциале, инвестициях в исследования и разработки, новых рыночных инициативах, глобальном присутствии, производственных площадках и объектах, производственных мощностях, сильных и слабых сторонах компании, запуске продукта, широте и широте продукта, доминировании приложений. Приведенные выше данные касаются только фокуса компаний на рынке.

Лидерами рынка эукариотических систем экспрессии являются:

• Agilent Technologies, Inc. (США)
• Merck KGaA (Германия)
• Bio-Rad Laboratories, Inc. (США)
• QIAGEN (Германия)
• Корпорация Promega (США)
• Thermo Fischer Scientific, Inc. (США)
• Takara Bio Inc. (Япония)
• GenScript (США)
• New England Biolabs (США)
• Oxford Expression Technologies Ltd (Великобритания)
• LifeSensors Inc. (США)
• Лонза (Швейцария)
• proteogenixx (Франция)
• Sysignature Discovery (Великобритания)
• Sino Biological Inc. (Китай)
• ARTES Biotechnology GmbH (Германия)

Последние разработки на рынке систем эукариотической экспрессии

• В октябре 2022 года компания объявила о планах по расширению своих лабораторий по разработке процессов и аналитических разработок клеточной и генной терапии (CGT) на своих объектах в Хьюстоне, Техас, и Гелине, Нидерланды. Это стратегическое расширение направлено на расширение ее возможностей в разработке инновационных решений CGT, отвечая на растущий спрос на передовые терапевтические возможности. Инвестируя в современные лаборатории, компания стремится ускорить исследования и разработки, в конечном итоге повышая эффективность и результативность своих терапевтических предложений в быстро меняющемся ландшафте биотехнологий.

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