Global Mixed Mode Chromatography Resin Market, By Technique (Ion Exchange – Hydrophobic and Hydroxyapatite), End-Use (Pharmaceutical and Biotechnology), Application (Antibodies Production, Vaccine Production, Non-Antibody Proteins, Antibody-Drug Conjugate, and Separation of Low Molecular Weight Impurities) - Industry Trends and Forecast to 2031.
Mixed Mode Chromatography Resin Market Analysis and Size
The mixed mode chromatography resin market is experiencing significant advancements, driven by the adoption of the latest methods and technologies. This growth is fueled by increased utilization across diverse industries such as biopharmaceuticals, food and beverages, and environmental analysis. The versatility and efficiency of mixed mode chromatography resins are propelling market expansion, with a focus on enhancing purification processes and achieving higher yields.
The global mixed mode chromatography resin market size was valued at USD 110.71 million in 2023 and is projected to reach USD 193.08 million by 2031, with a CAGR of 7.20% during the forecast period 2024 to 2031. In addition to the insights on market scenarios such as market value, growth rate, segmentation, geographical coverage, and major players, the market reports curated by the Data Bridge Market Research also include in-depth expert analysis, geographically represented company-wise production and capacity, network layouts of distributors and partners, detailed and updated price trend analysis and deficit analysis of supply chain and demand.
Report Scope and Market Segmentation
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Report Metric
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Details
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Forecast Period
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2024 to 2031
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Base Year
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2023
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Historic Years
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2022 (Customizable to 2016-2021)
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Quantitative Units
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Revenue in USD Million, Volumes in Units, Pricing in USD
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Segments Covered
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Technique (Ion Exchange – Hydrophobic and Hydroxyapatite), End Use (Pharmaceutical and Biotechnology), Application (Antibodies Production, Vaccine Production, Non-Antibody Proteins, Antibody-Drug Conjugate, and Separation of Low Molecular Weight Impurities)
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Countries Covered
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U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.
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Market Players Covered
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Bio-Rad Laboratories, Inc. (U.S.), HOYA Corporation (Japan), Tosoh India Pvt. Ltd. (Japan), Merck KGaA (Germany), Danaher Corporation (U.S.), Purolite (U.S.), General Electric Company (U.S.), Sartorius AG (Germany), Thermo Fisher Scientific, Inc. (U.S.), Geno Technology Inc. (U.S.), Sepragen Corporation (U.S.), Bio-Works (Sweden), DuPont (U.S.), Cytiva (U.S.), Sunresin New Materials Co.Ltd. (China), Anatrace Products, LLC (U.S.), and YMC Process Technologies (Japan)
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Market Opportunities
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Market Definition
Mixed mode chromatography resin contains ligands with both hydrophobic and ionic properties, allowing for simultaneous interaction with proteins based on charge, hydrophobicity, and size. This versatility enables efficient purification of biomolecules such as proteins, peptides, and nucleic acids. It provides greater selectivity and flexibility in separating complex mixtures, making it a valuable tool in biopharmaceutical and biochemical research.
Mixed Mode Chromatography Resin Market Dynamics
Drivers
- Increased Demand for Biopharmaceuticals
The surging demand for biopharmaceuticals, including monoclonal antibodies, vaccines, and recombinant proteins, is propelling the mixed mode chromatography resin market. Biopharmaceutical companies are seeking efficient purification techniques to ensure high product purity and yield. For instance, the increasing production of monoclonal antibodies for therapeutic purposes necessitates robust purification processes, where mixed mode chromatography resins excel in achieving the desired level of product purity and yield, thus driving their market growth.
- Rise in Adoption of Single-Use Technologies
The surge in single-use technologies within bioprocessing facilities is propelling the mixed mode chromatography resin market. These resins seamlessly integrate with disposable systems, streamlining operations and cutting costs. For instance, in the production of monoclonal antibodies, single-use chromatography systems employing mixed mode resins drastically reduce setup time and eliminate the need for cleaning validation, enhancing efficiency and productivity in bioprocessing operations.
Opportunities
- Expansion of Contract Manufacturing Organizations (CMOs)
The growing contract manufacturing sector, particularly in biopharmaceuticals, presents a prime avenue for mixed mode chromatography resin suppliers. As Contract Manufacturing Organizations (CMOs) strive to meet escalating demand, they prioritize efficient and cost-effective purification solutions. For instance, CMOs such as Catalent and Lonza increasingly rely on mixed mode chromatography resins to streamline bioprocessing operations, underscoring the pivotal role of these resins in supporting the expansion of contract manufacturing services.
- Advancements in Chromatography Resin Technology
Continuous advancements in chromatography resin technology, such as the creation of innovative ligands and enhanced resin matrices, are driving the mixed mode chromatography resin market forward. For instance, the development of novel ligands with specific binding properties and improved resin matrices with higher binding capacities has enabled superior performance and scalability in biopharmaceutical purification processes, meeting the industry's evolving needs efficiently.
Restraints/Challenges
- Complexity of Operation
The complexity of operating mixed-mode chromatography resins restricts their adoption, as users lacking specialized knowledge and experience find them challenging. This limitation hinders market growth by creating barriers to entry for potential users unfamiliar with the technology, diminishing the overall market potential for these chromatography resins.
- Column Packing Challenges
Column packing challenges hinder the mixed-mode chromatography resin market, with complexities arising from the intricate chemistry involved. These difficulties contribute to inconsistent column performance, discouraging adoption. This obstacle impacts the market's growth potential, impeding its widespread utilization within chromatography applications.
This market report provides details of new recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on the market contact Data Bridge Market Research for an Analyst Brief, our team will help you take an informed market decision to achieve market growth.
Impact and Current Market Scenario of Raw Material Shortage and Shipping Delays
Data Bridge Market Research offers a high-level analysis of the market and delivers information by keeping in account the impact and current market environment of raw material shortage and shipping delays. This translates into assessing strategic possibilities, creating effective action plans, and assisting businesses in making important decisions. Apart from the standard report, we also offer in-depth analysis of the procurement level from forecasted shipping delays, distributor mapping by region, commodity analysis, production analysis, price mapping trends, sourcing, category performance analysis, supply chain risk management solutions, advanced benchmarking, and other services for procurement and strategic support.
Expected Impact of Economic Slowdown on the Pricing and Availability of Products
When economic activity slows, industries begin to suffer. The forecasted effects of the economic downturn on the pricing and accessibility of the products are taken into account in the market insight reports and intelligence services provided by DBMR. With this, our clients can typically keep one step ahead of their competitors, project their sales and revenue, and estimate their profit and loss expenditures.
Recent Development
- In September 2022, Purolite unveiled a strategic alliance with PharmNXT Biotech, aiming to introduce its Praesto agarose-based Protein A and Ion Exchange chromatography resins to South Korea and Singapore. This partnership seeks to bolster the distribution and availability of the Praesto range, specifically targeting the South Korean market
- In September 2022, Tosoh Bioscience LLC launched the Octave BIO Multi-Column Chromatography (MCC) system, tailored for advancing pre-clinical processes. Distinguished by its versatile modular design, this system accommodates various resins, enhancing flexibility and efficiency in chromatographic applications for biotherapeutic development
- In June 2022, Bio-Rad Laboratories, Inc. launched EconoFit Chromatography Column Packs, tailored to support screening experiments with an array of resin options. These packs include prepacked columns featuring mixed-mode, cation, and anion resins, offering researchers the flexibility to select optimal chemistry for diverse target molecules in screening studies
- In June 2022, Tosoh Bioscience GmbH introduced SkillPak 50 and 200 pre-packed columns, designed for the development of a spectrum of biopharmaceuticals, including antibody fragments, viruses, antibody-drug conjugates (ADCs), monoclonal antibodies, and oligonucleotides. These columns streamline the chromatographic process, enhancing efficiency and reproducibility in bioprocess development
Mixed Mode Chromatography Resin Market Scope
The market is segmented on the basis of technique, end use and application. The growth amongst these segments will help you analyse meagre growth segments in the industries and provide the users with a valuable market overview and market insights to help them make strategic decisions for identifying core market applications.
Technique
- Ion Exchange – Hydrophobic
- Hydroxyapatite
End Use
- Pharmaceutical and Biotechnology
Application
- Antibodies Production
- Vaccine Production
- Non-Antibody Proteins
- Antibody-Drug Conjugate
- Separation of Low Molecular Weight Impurities
Mixed Mode Chromatography Resin Market Regional Analysis/Insights
The market is analysed and market size insights and trends are provided by technique, end use and application industry as referenced above.
The countries covered in the market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.
North America is expected to dominate the mixed mode chromatography resin market, propelled by increased investments in innovative research activities. The region benefits from the emergence of advanced technologies in various industries, further fueling market growth and driving adoption of these resins for diverse applications.
Asia-Pacific is expected to grow at the highest growth rate in the mixed mode chromatography resin market, driven by government initiatives supporting pharmaceutical and biotechnology industries. Investments and advancements in this region foster innovation, propelling the adoption of mixed mode chromatography resin for diverse bioprocessing applications.
The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as down-stream and upstream value chain analysis, technical trends and porter's five forces analysis, case studies are some of the pointers used to forecast the market scenario for individual countries. Also, the presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.
Competitive Landscape and Mixed Mode Chromatography Resin Market Share Analysis
The market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies' focus related to market.
Some of the major players operating in the market are:
- Bio-Rad Laboratories, Inc. (U.S.)
- HOYA Corporation (Japan)
- Tosoh India Pvt. Ltd. (Japan)
- Merck KGaA (Germany)
- Danaher Corporation (U.S.)
- Purolite (U.S.)
- General Electric Company (U.S.)
- Sartorius AG (Germany)
- Thermo Fisher Scientific, Inc. (U.S.)
- Geno Technology Inc. (U.S.)
- Sepragen Corporation (U.S.)
- Bio-Works (Sweden)
- DuPont (U.S.)
- Cytiva (U.S.)
- Sunresin New Materials Co.Ltd. (China)
- Anatrace Products, LLC (U.S.)
- YMC Process Technologies (Japan)
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