Mercado de terapia celular Natural Killer (NK) da América do Norte – Tendências do setor e previsão para 2030

Análise e insights do mercado de terapia celular Natural Killer (NK) da América do Norte

The North America natural killer (NK) cell therapeutics market comprises features such as the increasing need for better therapeutics options that will impact the launching of a new product by manufacturers into the market enhancing its demand as well as increasing investment in R&D leading to the market crescimento. Atualmente, estão a ser realizados vários estudos de investigação que deverão criar uma vantagem competitiva para os fabricantes desenvolverem novas e inovadoras terapias com células NK, o que deverá proporcionar várias outras oportunidades de crescimento de mercado. No entanto, espera-se que a falta de especificidade e a fraca sobrevivência in vivo das células, e o elevado custo associado às terapias, restrinjam o crescimento do mercado no período de previsão.

O mercado de terapêutica de células natural killer (NK) da América do Norte é favorável e visa reduzir a progressão da doença. A Data Bridge Market Research analisa que o mercado de terapêutica de células natural killer (NK) da América do Norte crescerá a um CAGR de 42,6% durante o período de previsão de 2023 a 2030.

O relatório do mercado de terapêutica celular natural killer (NK) da América do Norte fornece detalhes de quota de mercado, novos desenvolvimentos, análise de pipeline de produtos, o impacto dos participantes do mercado doméstico e localizado, analisa as oportunidades em termos de bolsas de receitas emergentes, alterações nas regulamentações de mercado, aprovações de produtos , decisões estratégicas, lançamentos de produtos, expansões geográficas e inovações tecnológicas no mercado. Para compreender a análise e o cenário do mercado, contacte-nos para um resumo do analista, a nossa equipa irá ajudá-lo a criar uma solução de impacto na receita para atingir o objetivo desejado.

Definição de mercado

As células natural killer (NK) são linfócitos granulares de grandes dimensões que têm a capacidade de responder rapidamente a um desafio patológico. São componentes importantes do sistema imunitário inato e desempenham um papel importante na geração de uma resposta imunitária contra malignidades e doenças infeciosas causadas por agentes patogénicos virais. Foram reconhecidos por induzirem a morte direta de células-alvo envolvendo células cancerígenas. Têm a capacidade de reconhecer uma infinidade de células infetadas sem depender de uma única célula que expressa o antigénio.

As células NK segregam citocinas e quimiocinas que recrutam outras células do sistema imunitário, como as células T e as células B, o que aumenta a resposta imunitária contra as células tumorais. Como as células NK não expressam recetores de células T, induzem um baixo risco de doença do enxerto contra o hospedeiro. Além disso, a terapia com células NK derivadas de linhas celulares iPSC, que é a terapia CAR-NK, supera a necessidade de um processo de fabrico longo e complexo que permite que os doentes com tumores agressivos possam pagar o tratamento do tumor o mais rapidamente possível . Juntamente com isto, as células NK derivadas de iPSC podem ser infundidas repetidamente, o que aumenta a resposta imunitária com regulação da dose.

Dinâmica do mercado de terapêutica celular natural killer (NK) da América do Norte

Esta secção trata da compreensão dos impulsionadores do mercado, vantagens, oportunidades, restrições e desafios. Tudo isto é discutido em detalhe abaixo:

MOTORISTAS

• Aumento da população de doentes com doenças crónicas

As doenças crónicas são doenças que geralmente ocorrem nos idosos e que podem ser controladas, mas não curadas, como as doenças cardíacas, a artrite, a diabetes, o acidente vascular cerebral ou o cancro. São uma preocupação mundial de problema de saúde. A mudança no estilo de vida, juntamente com a inatividade física, a alimentação pouco saudável e o consumo de tabaco, estão a aumentar o fardo das doenças crónicas em todo o mundo.

Um número crescente de doentes com doenças crónicas levou os cientistas e investigadores a trabalhar numa nova abordagem terapêutica inovadora, de modo a proporcionar aos doentes a melhor opção de tratamento curativo, que pode ser alcançada utilizando a terapia com células NK que tem o potencial de gerar uma forte resposta imunitária e tem também capacidade antitumoral.

• Aumentar a Sensibilização sobre Imunoterapias

As cancer is a devastating disease and available treatment options may cause the reoccurrence of tumors, the need for the best therapeutic approach is increasing day by day. Immunotherapies have attracted a lot of attention in recent years for the treatment of various types of malignancies. Among the immunotherapies, CAR–T cell therapies have been studied and were used as well but have several limitations, which led to the development of NK cell therapies. As a drug based on an NK cell therapeutic approach has not been approved yet, it thus needs to raise awareness among the population.

This is why several organizations and market players are launching a campaign to enhance awareness regarding NK cell therapies.

OPPORTUNITY

•  Strategic Initiatives by Market Players

Various strategic initiatives are adopted by market players which involve expansion, acquisition, and collaboration among others. These initiatives help them to increase the company’s product portfolio leading to market expansion and hence enhancing the product demand among customers, which ultimately leads the players to earn maximum revenue.

As the demand for effective and affordable NK cell immunotherapy is increasing worldwide, these strategic initiatives are taken by top market players aimed at enhancing business operations and earning more profitability in the market.

RESTRAINT/CHALLENGE

• Lack of Specificity and Poor In Vivo Survival of the cells

Lack of specificity and poor in-vivo survival of NK cells poses a challenge in front of manufacturers dealing in the market. The lack of specificity of NK cells leads to targeting the wrong cells, which can lead to ineffective treatment. Along with this, the lack of specificity and poor in-vivo survival of NK cells also reduces the therapeutic effect of administered NK cell therapy.

Such problems decrease the credibility of therapy used in clinical trials and pose a challenge in front of manufacturers while getting approval.

Recent Developments

• In January 2022, Takeda acquired Adaptate biotherapeutics to develop novel gamma delta (γδ) T cell engager therapies targeting solid tumors. Through the acquisition, Takeda will obtain Adaptate’s antibody-based γδ T cell engager platform, including pre-clinical candidate and discovery pipeline programs. Adaptate’s γδ T cell engagers are designed to specifically modulate γδ T cell-mediated immune responses at tumor sites while sparing damage to healthy cells. This acquisition helped the company to focus on R&D.
• In December 2021, Nektar Therapeutics announced phase 1b data for novel T regulatory cell stimulator NKTR-358 (LY3471851) in patients with atopic dermatitis. NKTR-358 is designed to treat autoimmune and inflammatory conditions by correcting the immune system imbalance that results from increased levels of inflammatory T cells and reduced numbers and impaired function of immune regulating Treg cells. This has helped the company to focus on R&D for further phases.

North America Natural Killer (NK) Cell Therapeutics Market Scope

The North America natural killer (NK) cell therapeutics market is segmented into five notable segments based on therapeutics, approaches, application, end-user, and distribution channel. The growth among these segments will help you analyze niche pockets of growth and strategies to approach the market and determine the core application areas and the difference in the target markets.

Therapeutics

• NK Cell Therapies
• NK Cell Directed Antibodies

Based on therapeutics, the market is segmented into NK cell therapies and NK cell directed antibodies.

Approaches

• Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)
• Bispecific Antibodies

Based on approaches, the market is segmented into antibody-dependent cell-mediated cytotoxicity (ADCC) and bispecific antibodies.

Application

• Cancer
• Immunoproliferative Disorders
• Acute Infectious Diseases
•  Gastrointestinal Diseases
• Others

Based on application, the market is segmented into cancer, immunoproliferative disorders, acute infectious diseases, gastrointestinal diseases, and others.

End User

• Research & Academic Institutes
• Hospitals
•  Specialty Clinics

Based on end user, the market is segmented into hospitals, specialty clinics, and research & academic institutes.

Distribution Channel

• Hospital Pharmacies
•  Direct Tender
•  Others

Based on distribution channel, the market is segmented into hospital pharmacies, direct tender, and others.

North America Natural Killer (NK) Cell Therapeutics Market Regional Analysis/Insights

The North America natural killer (NK) cell therapeutics market is categorized into five notable segments: therapeutics, approaches, application, end-user, and distribution channel.

The countries covered in this market report are the U.S., Canada, and Mexico.

The U.S. is dominating the North America natural killer (NK) cell therapeutics market and is expected to grow due to the rise in technological advancement in the market.

The country section of the report also provides individual market-impacting factors and changes in regulation in the market domestically that impact the current and future trends of the market. Data points such as new sales, replacement sales, country demographics, regulatory acts, and import-export tariffs are some of the major pointers used to forecast the market scenario for individual countries. Also, the presence and availability of North America brands and their challenges faced due to large or scarce competition from local and domestic brands, and the impact of sales channels are considered while providing forecast analysis of the country data.

Competitive Landscape and North America Natural Killer (NK) Cell Therapeutics Market Share Analysis

O panorama competitivo do mercado norte-americano de terapêutica celular natural killer (NK) fornece detalhes dos concorrentes. Os detalhes incluídos são a visão geral da empresa, finanças da empresa, receitas geradas, potencial de mercado, investimento em I&D, novas iniciativas de mercado, presença na América do Norte, localizações e instalações de produção, capacidades de produção, pontos fortes e fracos da empresa, lançamento de produto, largura e amplitude do produto e aplicação domínio. Os dados acima fornecidos estão apenas relacionados com o foco das empresas em relação ao mercado.

Alguns dos principais players que operam no mercado terapêutico norte-americano de células natural killer (NK) são a Merck KGaA, Bristol-Myers Squibb Company, Glycostem, Sanofi, Cytovia Therapeutics, ImmunityBio, Inc., Biohaven Pharmaceuticals, Fate Therapeutics, EMERcell, Phio Pharmaceuticals , PersonGen BioTherapeutics, Innate Pharma, Inc., INmuneBIO, Gamida Cell, Acepodia Inc., Affimed GmbH, Multimmune GmbH, iCell Gene Therapeutics, Takeda Pharmaceutical Company Limited e Regeneron Pharmaceuticals Inc., entre outras.

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