Visão geral do mercado global de processamento a jusante e previsão para 2031 – Análise de mercado e quota de mercado

Mercado Global de Processamento Downstream – Visão Geral da Indústria

O mercado global de processamento a jusante é um segmento crucial da indústria biofarmacêutica, com foco na purificação, isolamento e recuperação de produtos biofarmacêuticos a partir de processos de fermentação ou cultura celular. O mercado de processamento a jusante abrange várias fases principais, incluindo a colheita de células para remover células e detritos, a lise celular para libertar produtos intracelulares e a purificação através de técnicas avançadas de cromatografia, como afinidade, troca iónica e cromatografia de exclusão de tamanho. As inovações nas tecnologias de processamento a jusante, como resinas cromatográficas melhoradas, sistemas de utilização única e automação, estão a aumentar a eficiência, o rendimento e a relação custo-benefício, alimentando assim o crescimento global do mercado de processamento a jusante.

O relatório de mercado de pesquisa de mercado da Data Bridge fornece detalhes dos novos desenvolvimentos recentes, quota de mercado, tendências de mercado com base nas suas segmentações e análises regionais, o impacto dos participantes do mercado, análises de oportunidades em termos de bolsas de receitas emergentes, alterações nas regulamentações de mercado, estratégias análise de crescimento de mercado, tamanho de mercado, crescimento de mercado de categoria, nichos de aplicação e domínio, aprovações de produtos, lançamentos de produtos, expansões geográficas, inovações tecnológicas no mercado. Para mais informações sobre o mercado, contacte a equipa de analistas especializados da Data Bridge Market Research. A nossa equipa irá ajudá-lo a tomar decisões de mercado informadas para alcançar o crescimento do negócio.

Tamanho global do mercado de processamento a jusante

Biologics, including monoclonal antibodies, therapeutic proteins, and vaccines, require complex, and precise downstream processing to achieve high levels of purity, efficacy, and safety. As the healthcare industry increasingly relies on these advanced therapies to treat a range of conditions, from cancer to autoimmune disorders, the need for effective purification and recovery processes has surged. As a result, Databridge Market Research dived into comprehensively analyzing the market and unveiled that the Global Downstream Processing Market is increasing at a 11.3% CAGR of %. Our detailed analysis forecasts that the market is valued at USD 29.4 billion in 2023 and is expected to grow upto USD 69.23 billion by 2031. Our meticulously created report, developed through comprehensive research and analytics, is a distinguished paper that unveils eye-opening data about the market.

Global Downstream Processing Market Dynamics

Global Downstream Processing Market Growth Drivers

Automation and Process Integration

The integration of automation technologies, such as robotic systems and automated process controls improve downstream processing consistency, scalability, and dependability dramatically. Automated systems, such as the Ambr® 250 high-throughput bioreactor system, allow for the simultaneous culture of up to 24 bioreactors, speeding up development and manufacturing cycles. This improving efficiency, reducing operational costs, and supporting scalable production drives global downstream processing market growth.

Increasing Investment in Biopharmaceutical Manufacturing

Significant investment in biopharmaceutical production facilities, particularly in emerging areas such as Asia-Pacific, is driving up demand for downstream processing equipment and technology. For instance, Samsung Biologics and WuXi Biologics have made significant investments in developing their biomanufacturing capabilities, which has fueled the global downstream processing market growth.

Global Downstream Processing Market Growth Opportunities

Growing need for improved purification efficiency

Advances in chromatography and filtration technologies, such as high-resolution chromatography resins and advanced membrane filtration systems, significantly boost the efficiency and precision of biopharmaceutical purification. Such improvements lead to higher product yields and shorter processing times, driving growth in the global downstream processing market.

Rise in use of single-use systems

The use of single-use systems in downstream processing reduces the risk of cross-contamination, simplifies cleaning, and lowers operational expenses. By streamlining workflows and enhancing flexibility in biomanufacturing, single-use technologies are driving significant growth in the global downstream processing market.

Global Downstream Processing Market Growth Challenges

Environmental Concerns of Single-Use Technologies

Single-use technologies, while advantageous for reducing contamination risks and cutting operational costs, pose considerable environmental challenges due to the plastic waste they generate. The use of single-use bioreactors and disposable filters in the biopharmaceutical industry contributes to significant amounts of plastic waste. This issue is particularly severe in regions with stringent environmental regulations, such as California, where strict waste management and reduction practices are enforced. Companies operating in these areas face mounting pressure to adopt sustainable practices, such as investing in recyclable materials and enhancing waste disposal methods. These environmental concerns are a significant challenge for the global downstream processing market growth.

Global Downstream Processing Market Restraints

Regulations impeding market development

Regulatory compliance in downstream processing is challenging due to the rigorous standards imposed by agencies. For instance, in India, the Central Drugs Standard Control Organization (CDSCO) enforces stringent guidelines for downstream processing, particularly for biopharmaceuticals. These guidelines emphasize comprehensive process validation and the implementation of quality by design (QbD) principles to ensure consistent product quality throughout the manufacturing process. Such stringent requirements can create significant barriers and increase the complexity and cost of bringing new products to market, acting as a restraint on the global downstream processing market growth.

Global Downstream Processing Market Scope and Trends

• Innovations in chromatography resins, such as those providing higher resolution and greater binding capacities, have improved the purification of complex biopharmaceuticals. For instance, new resins designed for Protein A affinity chromatography such as Thermo Scientific MabCaptureC enhance the purity of monoclonal antibodies by increasing their binding specificity and reducing impurities.
• Depth filters and tangential flow filtration (TFF) systems have been upgraded with advanced materials and designs, boosting throughput and minimizing fouling to enhance separation efficiency in filtration technologies.
• Ambr 250 high-throughput bioreactor, enable real-time monitoring and adjustment of concentration levels, which improves process control and reduces processing times.
• Single-use filtration and concentration systems are gaining popularity due to their ease of use and reduced risk of cross-contamination. These systems, including single-use membrane filters and concentrators, simplify the process by eliminating the need for extensive cleaning and validation.

Global Downstream Processing Market Regional Analysis – Market Trends

Key Insights

• The United States dominates the worldwide downstream processing market due to its mature biopharmaceutical industry and significant investment in innovative technology. For instance, large biopharmaceutical companies and contract manufacturing organizations (CMOs) like as Thermo Fisher Scientific and Lonza have significant downstream processing facilities, which drive market growth through innovation and technological advancements.
• Asia-Pacific region is experiencing rapid growth driven by increasing biopharmaceutical manufacturing capabilities in countries like China and India. For instance, WuXi AppTec, a prominent Chinese biopharmaceutical company, is expanding its downstream processing capacity to support the rising demand for biologics and biosimilars.
• The European market is expanding with advanced bioprocessing facilities in countries like Germany and Switzerland. The region’s adherence to stringent regulatory standards, such as those set by the European Medicines Agency (EMA), ensures high-quality production. Companies like Sartorius and Eppendorf are key contributors to the market, offering sophisticated downstream processing technologies and solutions.

Leading Players in the Global Downstream Processing Market

• 3M
• Repligen Corporation
• Boehringer Ingelheim International GmbH
• Eppendorf AG
• Lonza
• Corning Incorporated
• Asahi Kasei Corporation
• Dover Corporation
• Thermo Fisher Scientific Inc.
• GENERAL ELECTRIC COMPANY
• Sartorius AG
• Merck KGaA, Darmstadt, Germany and/or its affiliates
• Danaher
• Fenner Group Holdings Limited

Global Downstream Processing Market Recent Developments

• In Feb, 2024 ASF SE, headquartered in Ludwigshafen, Germany, officially announced the start of the divestiture process for its shares in two joint venture firms, BASF Markor Chemical Manufacturing (Xinjiang) Co, Ltd and Markor Meiou Chemical (Xinjiang) Co, Ltd, both based in Korla.
• Em janeiro de 2024, a MilliporeSigma investiu mais de 300 milhões de euros (326 milhões de dólares) para construir um centro de produção de bioprocessamento em Daejeon, na Coreia do Sul. O centro irá apoiar e fornecer uma variedade de produtos biotecnológicos, incluindo líquidos de processo, meio de cultura celular em pó seco, produção em pequena escala e dispositivos de amostragem estéreis.
• Em maio de 2024, a Greenwave Technology Solutions, Inc., uma operadora de instalações de reciclagem de metal na Virgínia, Carolina do Norte e Ohio, informou que o seu sistema de processamento a jusante alcançou receitas recorde devido ao aumento do volume e aos preços mais elevados .
• Em junho de 2024, a Sartorius uniu forças com a Sanofi para co-desenvolver e comercializar uma plataforma integrada de biofabricação contínua (ICB) destinada a melhorar a eficiência a jusante. A Sartorius utilizará a sua experiência em hardware, consumíveis e automatização de processos em todas as fases, desde o desenvolvimento até à comercialização.

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