Unlocking Genomic Mysteries: Advancements and Applications of Long Read Sequencing Technologies in Biomedical Research

The global long read sequencing market utilizes advanced technologies for highly accurate and extensive DNA decoding. Long read sequencing, a transformative genomics approach, overcomes short-read sequencing limitations. It analyzes large genetic stretches, unraveling complex genomic structures and detecting disease-related variations. Also known as third generation sequencing, it involves real-time DNA sequencing, producing long reads without PCR amplification. Key techniques of long read sequencing market value include single molecule real-time (SMRT) sequencing and nanopore sequencing, contributing to a comprehensive understanding of genetic information and driving advancements in genomics.

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Data Bridge Market Research analyses that the Global Long Read Sequencing Market value was USD 519.64 million in 2022, and is expected to reach USD 2,533.57 million by 2030, and is expected to undergo a CAGR of 21.9% during the forecast period 2023-2030. Long-read sequencing is pivotal in advancing precision medicine and tailoring treatments to individual genetic variations. This technology enhances our ability to decipher complex genomic information, guiding personalized medical interventions for improved patient outcomes.

Key Findings of the Study

Surge in incidences of genetic disorders is expected to drive the market's growth rate

The rising incidence of genetic disorders, such as sickle cell disease, affecting around 100,000 individuals in the U.S., is a significant driver for the market's growth. As patient numbers increase, key companies will invest in innovative solutions, anticipating market expansion. This surge in genetic disorder cases is expected to draw attention and drive the market's progress shortly, addressing the growing need for advanced diagnostics and therapeutic interventions.

Report Scope and Market Segmentation

Segment Analysis:

The global long-read sequencing market is segmented on the basis of technology, product, workflow, application, and end-user. 

• On the basis of technology, the global long read sequencing market is segmented into single-molecule real- time sequencing, nanopore sequencing, synthetic long read sequencing, and others
• On the basis of product, the global long read sequencing market is segmented into instruments, consumables and services
• On the basis of workflow, the global long read sequencing market is segmented into pre-sequencing, sequencing and data analysis
• On the basis of application, the global long read sequencing market is segmented into whole genome sequencing, epigenetics, RNA sequencing, complex population, targeted sequencing and others
• On the basis of end-user, the global long read sequencing market is segmented into academic and research institutes, clinical laboratories, hospitals, pharma and biotech entities and others

Major Players

Data Bridge Market Research recognizes the following companies as the major global long read sequencing market players in global long read sequencing market are BaseClearB.V (Netherlands), INSTITUTE OF INTEGRATIVE CELL BIOLOGY AND PHYSIOLOGY (France), France Génomique (France), Takara Holdings Inc. (Japan), Genexa AG (Switzerland)

Market Developments

• In October 2022, PacBio launched the Revio long-read sequencing system and the Onso short-read sequencing system. The Revio system integrates deep-learning methods for detecting DNA methylation directly from standard sequencing libraries, enhancing the platform's capabilities in providing comprehensive genomic insights. These advancements signify PacBio's commitment to advancing genomic research through cutting-edge sequencing technologies
• In March 2022, Element Biosciences launched the Aviti DNA sequences, a highly anticipated benchtop instrument. Employing a unique sequencing-by-synthesis chemistry variation, the technology minimizes reagent consumption, costing around USD 7 per gigabyte. This innovation signifies a significant stride in making genomic sequencing more cost-effective and accessible, potentially impacting various research and clinical applications
• In March 2020, Thermo Fisher Scientific Inc. successfully acquired QIAGEN N.V. for Euro 39 per share in cash. This strategic move enhances Thermo Fisher's product portfolio, fostering revenue growth and expanding its global market presence. The acquisition solidifies Thermo Fisher's position in the life sciences and diagnostics sector, amplifying its capabilities to meet evolving industry demands and deliver innovative solutions to a broader customer base
• In February 2020, Oxford Nanopore Technologies collaborated with NuProbe, integrating Nanopore sequencing with NuProbe’s blocker displacement amplification technology. This collaboration enhances detection sensitivities, enabling the quantification of somatic mutations at less than 5% allele frequency. The strategic alliance broadens Oxford Nanopore's product applications, fostering advancements in genomic research and precision medicine

Regional Analysis

Geographically, the countries covered in the global long read sequencing market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America

As per Data Bridge Market Research analysis:

North America is the dominant region in the global long read sequencing market during the forecast period 2023-2030

North America dominates the global long read sequencing market during the forecasted period owing to many companies, robust research and development capabilities, and advancements in the field. The region's strong presence in long-read sequencing is attributed to a high concentration of key industry players, raising innovation and technological innovations that position North America as a leader in shaping the trajectory of the global long-read sequencing landscape.

Asia-Pacific is estimated to be the fastest-growing region in the global long read sequencing market during the forecast period 2023-2030

Asia-Pacific is expected to dominate the global long read sequencing market, experiencing substantial growth from 2023 to 2030. The region's accelerated development is attributed to leading players expanding into emerging Asian markets. The robust progress in forward-thinking diagnostics projects also enhances the regional market's strength. This upward trajectory underscores the increasing significance of long read sequencing technologies in advancing genomics and diagnostics across the Asia-Pacific region.

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