世界のオピオイド誘発性便秘薬市場 – 業界動向と2031年までの予測

オピオイド誘発性便秘薬市場分析と規模

国立バイオテクノロジー情報センターが発表した報告書によると、慢性疼痛は3か月以上続く持続的な不快感を特徴とし、人口の約10～15%に影響を及ぼしています。慢性非癌性疼痛を経験する人のうち、オピオイド誘発性便秘の有病率は41%～81%です。

世界のオピオイド誘発性便秘薬市場規模は、2023年に26億9,000万米ドルと評価され、2024年から2031年の予測期間中に6.7%のCAGRで成長し、2031年までに45億2,000万米ドルに達すると予測されています。市場価値、成長率、セグメンテーション、地理的範囲、主要プレーヤーなどの市場シナリオに関する洞察に加えて、Data Bridge Market Researchがまとめた市場レポートには、詳細な専門家分析、患者の疫学、パイプライン分析、価格分析、規制枠組みも含まれています。

レポートの範囲と市場セグメンテーション       

市場の定義

オピオイド誘発性便秘薬は、オピオイド鎮痛剤の使用によって引き起こされる便秘を緩和するために特別に設計された薬です。これらの薬は、オピオイドの影響を受ける消化管の受容体を標的にして作用し、オピオイドの鎮痛効果を妨げることなく、正常な腸機能を回復させ、便秘を緩和します。これらは、オピオイド療法の副作用として便秘を経験する人々にとって、疼痛管理戦略の不可欠な要素です。      

オピオイド誘発性便秘薬市場の動向

ドライバー

• オピオイド使用の増加

鎮痛のためのオピオイド処方の増加により、世界中でオピオイド誘発性便秘（OIC）の発生率が大幅に増加しています。オピオイドは、がん関連の痛みや重傷などの慢性疼痛に処方されることが多く、OICを経験する人の数の増加につながっています。その結果、オピオイド療法のこの一般的な副作用を管理し、患者の生活の質を向上させるための効果的なOIC薬の必要性が高まっており、これが市場の成長を促進する主な要因となっています。

• 医薬品承認の迅速化に向けた取り組み

規制当局は、新しいオピオイド誘発性便秘（OIC）薬の承認プロセスを迅速化するプログラムを実施しています。これらの取り組みは、薬剤の開発と承認に必要な時間とリソースを削減することで、効果的な治療の緊急ニーズに対応することを目的としています。規制プロセスを簡素化することで、製薬会社は新しい OIC 薬をより早く市場に投入し、患者が革新的な治療をより早く受けられるようにすることができます。この迅速な承認経路は、OIC 薬市場の拡大に大きく貢献しています。 

• 薬物送達技術の進歩

Continuous innovations in drug delivery technology are driving the development of more effective and patient-friendly opioid-induced constipation (OIC) drugs. Novel delivery systems, such as controlled-release formulations and targeted drug delivery mechanisms, are designed to optimize OIC drugs' therapeutic effects while minimizing adverse effects like constipation. These advancements improve patient compliance and satisfaction and enhance the overall efficacy and safety profiles of OIC medications. Consequently, the evolution of drug delivery technology acts as a significant driver for the market's growth, fostering innovation and market expansion.

Opportunities

• Expanding Geriatric Population 

As the global population ages, there is a notable increase in the number of elderly individuals who require opioid therapy for chronic pain management. This demographic is more susceptible to opioid-induced constipation (OIC) due to age-related changes in gastrointestinal function. Addressing the specific requirements of older population such as dosage adjustments and personalized treatment plans can create new opportunities for market growth.       

• Personalized OIC Treatments

Tailored OIC therapies can address specific patient needs, potentially reducing side effects and improving treatment efficacy. This patient-centered approach aligns with the broader trend toward personalized healthcare, offering more targeted and efficient solutions for managing OIC.      Personalized OIC treatments can optimize treatment plans, ensuring patients receive the most effective therapies for their specific condition. This can lead to improved symptom management and overall treatment efficacy, which will help new opportunities arise in the market.

Restraints/Challenges

• Safety Concerns Impacting OIC Drugs

The safety profile of opioid medications, including the potential for addiction and overdose, significantly influences the adoption and use of opioid-induced constipation (OIC) drugs. Healthcare providers and patients are often wary of using opioids due to these safety concerns, which can lead to hesitancy in prescribing and reluctance in seeking treatment and create challenges for the market.    

• Stigma and Misconceptions

There is a stigma associated with opioid use, which can lead to misconceptions about the need for OIC drugs and reluctance among patients to seek treatment. This stigma can also impact healthcare provider attitudes and prescribing practices, affecting the uptake of OIC drugs and hindering market growth.

This opioid induced constipation drugs market report provides details of new recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on the opioid induced constipation drugs market contact Data Bridge Market Research for an Analyst Brief, our team will help you take an informed market decision to achieve market growth.

Recent Developments

• In March 2022, Bausch Health Companies Inc. and its gastroenterology division, Salix Pharmaceuticals, announced research findings indicating that patients who received FDA-approved prescription medications for opioid-induced constipation (OIC-Rx), such as RELISTOR subcutaneous injection (SC) (methylnaltrexone bromide), in the emergency department (ED) were less likely to require hospitalization. Moreover, those who were hospitalized had shorter stays compared to patients who did not receive OIC-Rx in the ED. These results underscore the potential of RELISTOR SC to offer relief for individuals with OIC.  
• In January 2022, BioGaia Pharma reported the enrollment of the first patient in a Phase II clinical study evaluating BGP345A for the treatment of opioid-induced constipation (OIC-1).
• In February 2021, Cosmo Pharmaceuticals revealed a partnership with RedHill Biopharma Ltd. for the production of Movantik, intended for the treatment of opioid-induced constipation (OIC) in adult patients.        

Opioid Induced Constipation Drugs Market Scope

The opioid induced constipation drugs market is segmented on the basis of active ingredient, treatment, route of administration, distribution channel, and end-user. The growth amongst these segments will help you analyze meagre growth segments in the industries and provide the users with a valuable market overview and market insights to help them make strategic decisions for identifying core market applications.

Active Ingredients

• Naloxegol
• Lubiprostone
• Methylnaltrexone Bromide
• Docusate Sodium
• Others

 Treatment

• Over The Counter Medicines
• Prescription
• Natural Remedies

Route of Administration

• Oral
• Parenteral
• Others

End-Users

• Hospitals
• Homecare
• Speciality Centres
• Others

Distribution Channel

• Hospital Pharmacy
• Online Pharmacy
• Retail Pharmacy

Global Opioid Induced Constipation Drugs Market Regional Analysis/Insights

The opioid induced constipation drugs market is analyzed and market size insights and trends are provided by country, active ingredient, treatment, route of administration, distribution channel, and end-user as referenced above.

The countries covered in the market are U.S., Canada, Mexico, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific, Saudi Arabia, U.A.E., South Africa, Egypt, Israel, Rest of Middle East and Africa, Brazil, Argentina, and Rest of South America.

North America is expected to dominate the market due to the presence of major product manufacturers, which contributes to a robust market presence and availability of OIC drugs. The region is witnessing a significant increase in research and development efforts aimed at developing innovative treatments for OIC, further driving market growth. Substantial healthcare expenditure for addressing gastrointestinal disorders, including OIC, underscores the importance and demand for effective OIC drugs in the region.

Asia-Pacific is expected to witness significant growth due to the increase in new research and developments concerning opioid-induced constipation drugs. The region benefits from advanced healthcare infrastructure availability and earlier drug approvals for opioid-induced constipation drugs, courtesy of the accelerated drug approval initiative by the U.S. FDA, which is likely to propel market growth.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points like down-stream and upstream value chain analysis, technical trends and porter's five forces analysis, case studies are some of the pointers used to forecast the market scenario for individual countries. Also, the presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.

Healthcare Infrastructure Growth Installed base and New Technology Penetration

The opioid induced constipation drugs market also provides you with detailed market analysis for every country growth in healthcare expenditure for capital equipment, installed base of different kind of products for opioid induced constipation drugs market, impact of technology using life line curves and changes in healthcare regulatory scenarios and their impact on the opioid induced constipation drugs market. The data is available for historic period 2011-2021.

Competitive Landscape and Opioid Induced Constipation Drugs Market Share Analysis

The opioid induced constipation drugs market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies' focus related to the market.

Some of the major players operating in the market are:

• Pfizer Inc (U.S.)
• F. Hoffmann-La Roche Ltd (Switzerland)
• Mylan N.V. (U.S.)
• Fresenius Kabi AG (Germany)
• Hikma Pharmaceuticals PLC (U.K.)
• Novartis AG (Switzerland)
• Teva Pharmaceutical Industries Ltd. (Israel)
• Bristol Myers Squibb Company (U.S.)
• GSK Plc. (U.K.)
• Bayer AG (Germany)
• Aurobindo Pharma (India)
• S.L.A. Pharma AG (U.K.)
• Salix Pharmaceuticals (U.S.)
• Takeda Pharmaceutical Company Limited (Japan)
• Abbott(U.S.)
•  Boehringer Ingelheim International GmbH. (Germany)
• Merck & Co Inc. (U.S.)
• Daewoong Pharmaceutical Company (South Korea)
•  Cosmo Pharmaceuticals (Ireland)

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