Marché mondial du traitement de la maladie de Huntington – Tendances et prévisions du secteur jusqu'en 2030

Analyse et taille du marché du traitement de la maladie de Huntington

La maladie de Huntington touche environ 30 000 personnes en Amérique du Nord, avec une incidence de 5,7 pour 100 000 personnes. Elle n'est pas si courante chez les enfants. La maladie de Huntington devrait connaître d'énormes développements dans les années à venir, à mesure que les médicaments modificateurs de la maladie transforment le paysage du marché. Les dernières recherches sur cette maladie se concentrent principalement sur l'utilisation de nouveaux traitements tels que les thérapies immunomodulatrices, les micro-ARN (miARN), la thérapie génique (utilisant des oligonucléotides antisens, l'épissage de l'ARNm et la protéine de liaison à l'ADN à doigt de zinc (ZFP)).  

Data Bridge Market Research analyse le taux de croissance du marché du traitement de la maladie de Huntington au cours de la période de prévision 2023-2030. Le TCAC attendu du marché du traitement de la maladie de Huntington a tendance à être d'environ 20 % au cours de la période de prévision mentionnée. Le marché était évalué à 0,39 milliard USD en 2022 et devrait atteindre 1,68 milliard USD d'ici 2030. En plus des informations sur le marché telles que la valeur marchande, le taux de croissance, les segments de marché, la couverture géographique, les acteurs du marché et le scénario du marché, le rapport de marché organisé par l'équipe de Data Bridge Market Research comprend également une analyse approfondie des experts, une épidémiologie des patients, une analyse du pipeline, une analyse des prix et un cadre réglementaire.

Portée et segmentation du marché du traitement de la maladie de Huntington

Market Definition

Huntington’s disease is a rare inherited disease that causes progressive breakdown  of nerve cells in the brain, mainly affecting physical movements, emotions and cognitive abilities. The symptoms of this disease can appear at any time but mostly appear at the age of 30-40 years. If the condition appears before 20 years of age, this disorder is said to be juvenile Huntington’s disease.

Global Huntington’s Disease Treatment Market Dynamics

Drivers

• Rising Prevalence of Huntington’s Disease

Huntington’s Disease (HD) is a progressive neurological condition caused by CAG expansions in the Huntingtin (Htt) gene. It affects 1 out of every 10,000 people in the U.S. Healthy people mostly have less than 35 CAG repetitions, whereas, HD patients have CAG expansions which ranges from 36 to 200. The incidence varies by more than 10-fold between geographical locations, that can be related to variations in case ascertainment and diagnostic criteria.  

• Increasing Demand For Disease-Modifying Therapies

The disease-modifying therapies segment is estimated to witness the huge growth during the forecast period. This is because of an increase in R&D for disease-modifying therapy along with an increase in the need for advanced products, such as gene therapy and stem cell therapy. The government initiatives such as Fast Track Designation by the U.S. FDA for increasing the registration process may increase the market in the upcoming years. For instance, in 2021, U.S. FDA granted fast track designation to Sage Therapeutics’s drug, SAGE-718, as a budding treatment for Huntington’s disease.

Opportunities

• Increased Clinical Research Activities

There have been increasing clinical research activities for various drug development processes that are boosting the market's growth. For instance, Annexon, Inc. is engaged in the development of ANX005-an experimental monoclonal antibody which targets abnormal C1q activity in complement-mediated neurodegenerative diseases, such as Huntington’s Disease. This is administered intravenously (IV) and is meant to suppress C1q and the complete classical complement system. Furthermore, in 2020, the company initiated a phase 2 clinical trial of ANX005 for the treatment of HD patients. Stem cell therapy is also generating interest as a potential treatment for HD. Presently, Cellavita, in collaboration with AzidusPharma, is investigating stem cell therapy, CELLAVITA-HD in phase 2/ 3 ADORE-DH trial.   

• Increasing Drug Approvals

There have been increasing drug approvals for the treatment of HD patients. For instance, in 2020, Teva Pharmaceutical Industries Ltd. received NMPA approval for Austedo in China for treating cholera associated with Huntington’s disease. This expansion of the company is expected to increase the patient base and the revenue growth.

 Restraints/Challenges

• Limited Availability of Drugs

The number of approved drugs for Huntington’s disease are restricted due to strict policies and regulations. This is expected to hamper the market growth during the forecast period. Additionally, the lack of awareness about this disorder in major parts of the world is expected to limit the growth of Huntington’s disease treatment market.

• Discontinuation of Drug Trials

The drug development for the disease has faced major obstacles as numerous therapies have failed to demonstrate efficacy or were related with major toxicity. For instance, in 2021, F. Hoffmann-La Roche Ltd. discontinued the dosing in the phase III GENERATION HD1 study of tominersen in manifest HD. This conclusion was made on the basis of findings of an unblinded Independent Data Monitoring Committee's (iDMC) pre planned examination of data from the phase III research.

This Huntington’s disease treatment market report provides details of new recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on the Huntington’s disease treatment market contact Data Bridge Market Research for an Analyst Brief, our team will help you take an informed market decision to achieve market growth.

COVID-19 Impact on Global Huntington’s Disease Treatment Market

During the pandemic, the sales of off-label drugs such as antidepressants, antipsychotics, and anticonvulsant were done through online pharmacies to manage symptoms associated with HD. The conduction of clinical trials was hindered because of the government-imposed lockdown during the COVID-19 pandemic.

In the post pandemic era, most hospitals and clinics worldwide reported that clinical visits frequency for the diagnosis and treatment of HD has improved. As a result, the market will grow with the estimated growth rate. The clinical trials for Huntington’s disease treatment development have increased post-pandemic.

Recent Developments:

• In 2021, NeuExcell Therapeutics Inc partnered with Spark Therapeutics, Inc. to develop gene therapy for the treatment of HD patients. Under the agreement, NeuExcell Therapeutics is meant to receive upfront license fees, R&D, and sales milestone payments of up to approximately USD 190 million and additional product royalties

Global Huntington’s Disease Treatment Market Scope

The Huntington’s disease treatment market is segmented on the basis of type, medication, route of administration, distribution channel and end-user. The growth amongst these segments will help you analyze meagre growth segments in the industries and provide the users with a valuable market overview and market insights to help them make strategic decisions for identifying core market applications.

Type

• Adult Onset
• Early Onset

Medication

• Medication
• Therapy

Route of Administration

• Oral
• Parenteral
• Others

End User

• Hospitals
• Homecare
• Specialty Clinics
• Others

Distribution Channel

• Hospital Pharmacy
• Online Pharmacy
• Retail Pharmacy

 Huntington’s Disease Treatment Market Regional Analysis/Insights

The Huntington’s disease treatment market is analyzed and market size insights and trends are provided by type, medication, route of administration, distribution channel and end-user as referenced above.

The major countries covered in the Huntington’s disease treatment market report are the U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

Asia-Pacific will expect positive growth for Huntington’s disease treatment market throughout the forecasted period due to rising infrastructure of research health care and expenditure for R&D activities.  

North America dominates the market due to the increasing awareness about the diseases and presence of key manufacturer players.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Also, the presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.   

Competitive Landscape and Global Huntington’s Disease Treatment Market Share Analysis

Le paysage concurrentiel du marché du traitement de la maladie de Huntington fournit des détails par concurrent. Les détails inclus sont la présentation de l'entreprise, les finances de l'entreprise, les revenus générés, le potentiel du marché, les investissements dans la recherche et le développement, les nouvelles initiatives du marché, la présence mondiale, les sites et installations de production, les capacités de production, les forces et les faiblesses de l'entreprise, le lancement du produit, la largeur et l'étendue du produit, la domination des applications. Les points de données ci-dessus fournis ne concernent que l'orientation des entreprises liées au marché du traitement de la maladie de Huntington.

Les principaux acteurs opérant sur le marché du traitement de la maladie de Huntington comprennent :

• Teva Pharmaceutical Industries Ltd (Israël)
• Amneal Pharmaceuticals LLC. (États-Unis)
• Elekta AB (Suède)
• Alnylam Pharmaceuticals, Inc (États-Unis)
• Apotex Inc. (Canada)
• Armata Pharmaceuticals, Inc. (États-Unis)
• Pfizer Inc (États-Unis)
• H. Lundbeck A/S (Danemark)
• Alterity Therapeutics (Australie)
• Vertex Pharmaceuticals Incorporated (États-Unis)
• SK Plc. (Royaume-Uni), Ceregene, Inc (États-Unis)
• SOM BIOTECH (Espagne)
• Palobiofarma (Espagne)
• Ipsen Pharma (France)

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