The COVID-19 saliva screening test potential market has emerged as a crucial segment in diagnostic testing, driven by advancements in technology and the growing demand for non-invasive, accurate, and rapid diagnostic solutions. Saliva-based testing has gained significant attention due to its ease of collection, reduced reliance on healthcare professionals, and minimal discomfort for patients compared to nasopharyngeal swabs. These features make it an ideal solution for mass testing programs in schools, workplaces, and public venues. Technological innovations, such as CRISPR-based diagnostics and fluorescence-labeled antigen/antibody testing, have further enhanced the accuracy and efficiency of saliva tests. For instance, the U.S.-based firm Fluidigm Corporation developed a saliva RT-PCR assay that offers high sensitivity and rapid results. In addition, collaborations between government agencies and companies, such as BARDA's partnership with Aptitude Medical Systems in 2023, underscore the commitment to expanding access to these diagnostic tools. North America currently leads the market due to its advanced healthcare infrastructure and high adoption of innovative diagnostics. Meanwhile, Europe is poised for rapid growth, fueled by increasing awareness and government support. As testing remains integral to pandemic control, the COVID-19 saliva screening test market is expected to witness sustained growth and innovation.