Global Gene Synthesis Market – Industry Trends and Forecast to 2031

Global Gene Synthesis Market, By Component (Synthesizer, Consumables, and Software and Services), Gene Type (Standard Gene, Express Gene, Complex Gene and Others), Gene Synthesis Type (Gene Library Synthesis, and Custom Gene Synthesis), Application (Synthetic Biology, Genetic Engineering, Vaccine Design, Therapeutics Antibodies, and Others), Method (Solid Phase Synthesis, Chip-Based DNA Synthesis, and PCR-Based Enzyme Synthesis), End User (Academic and Research Institutes, Diagnostics Laboratories, Biotech and Pharmaceutical Companies, and Others), Distribution Channel (Direct Tender, Online Distribution, and Third Party Distributors) – Industry Trends and Forecast to 2031.

Gene Synthesis Market Analysis and Size

In agricultural biotechnology, the gene synthesis market plays a vital role in enhancing crop traits and improving agricultural productivity. Through gene synthesis, researchers engineer genetic modifications in crops to confer desirable traits such as pest resistance, drought tolerance, and increased yield. This technology enables the development of genetically modified (GM) crops with improved traits, addressing challenges such as crop diseases, environmental stresses, and food scarcity. Gene synthesis facilitates the rapid and precise introduction of beneficial genes into crop genomes, accelerating the breeding process and enabling the creation of crops better suited to modern agricultural needs.

For Instance,

According NCBI, The development of various DNA markers since the introduction of molecular marker technologies such as RFLP and PCR in 1980 has revolutionized biology research. DNA markers such as RAPD, SNP, AFLP, and SRAP offer greater information content and polymorphism compared to traditional markers. They are versatile tools widely utilized in agricultural biotechnology for tasks such as identifying crop varieties, conserving and evaluating plant germplasm, analyzing genetic diversity and evolution, constructing genetic maps, and facilitating molecular marker-assisted breeding.

Global gene synthesis market size was valued at USD 2.65 billion in 2023 and is projected to reach USD 13.79 billion by 2031, with a CAGR of 22.90% during the forecast period of 2024 to 2031. In addition to the insights on market scenarios such as market value, growth rate, segmentation, geographical coverage, and major players, the market reports curated by the Data Bridge Market Research also include depth expert analysis, patient epidemiology, pipeline analysis, pricing analysis, and regulatory framework.

Gene Synthesis Market Scope and Segmentation  

Market Definition

Gene synthesis is the artificial creation of DNA sequences, typically using chemical methods or automated DNA synthesis machines. It allows researchers to design and produce custom DNA molecules with specific sequences, enabling the study of gene function, protein expression, and genetic engineering.

Gene Synthesis Market Dynamics

Drivers

• Growing Integrated DNA Technologies Leads to the Rise in Demand for Gene Synthesis Services

IDT gene blocks are customized DNA fragments synthesized to precise specifications, offering researchers a versatile tool for molecular biology applications. IDT's reputation for high-quality synthesis, reliability, and customization capabilities attracts researchers across various disciplines, fueling demand for gene synthesis services. The ease of ordering, quick turnaround times, and competitive pricing of IDT gene blocks enhance their appeal, contributing to market growth. Moreover, their compatibility with a wide range of downstream applications, including PCR, cloning, and gene expression studies, solidifies their position as a preferred choice among researchers and drives the expansion of the gene synthesis market.

For Instance,

In September 2023, Integrated DNA Technologies (IDT) announced the launch of xGen products tailored for Ultima Genomics, marking a significant advancement in the gene synthesis market. This strategic move aligns with IDT's commitment to innovation and customization, catering to the evolving needs of researchers in molecular biology. The introduction of xGen products for Ultima Genomics underscores IDT's dedication to providing cutting-edge solutions, further solidifying its position as a key driver of gene synthesis market growth. Researchers can now leverage these specialized products to enhance their molecular biology workflows, thereby amplifying demand for IDT's gene synthesis services and contributing to market expansion.

• Increasing Research Activities Promotes the Synthetic Genes Across Diverse Fields

As research endeavors expand in areas such as pharmaceuticals, agriculture, and healthcare, there arises a greater need for customized genetic materials for various applications, including drug development, genetic engineering, and disease modeling. The exploration of novel gene functions, pathways, and therapeutic targets necessitates efficient gene synthesis services and products. The market experiences growth spurred by the continuous quest for innovative solutions and discoveries in biotechnology and life sciences, driving the adoption of gene synthesis technologies.

For Instance,

The laboratory's development of an improved device for segmented synthesis of oligonucleotides, as reported by NCBI, aligns with the increasing research activities driving the usage of gene synthesis. This innovation promises to significantly enhance the speed and efficiency of gene synthesis processes. Simultaneously synthesizing up to 100 different DNA sequences using porous Teflon wafers, the new device offers a step-change in synthesis capability, achieving comparable coupling efficiency to current automated methods while utilizing substantially fewer reagents. Such advancements underscore the continuous quest for innovation in gene synthesis technologies, contributing to the market's growth and adoption.

Opportunities

• Rising Healthcare Expenditure Results in Increased Improving Patient Outcomes

As healthcare spending increases globally, there is a growing emphasis on precision medicine and personalized therapies, which often rely on custom-designed synthetic genes. Gene synthesis enables the development of tailored treatments for various diseases, including cancer and genetic disorders, driving its adoption in clinical research and therapeutics. Moreover, as healthcare systems seek cost-effective solutions and innovative approaches to address complex medical challenges and gene synthesis price, offers a promising avenue for advancing precision healthcare and improving patient outcomes.

• Expansion of Synthetic Biology Increasing Demand for Custom-Designed DNA Constructs

As synthetic biology techniques advance, there is an increasing demand for custom-designed DNA constructs and synthetic genes to enable the engineering of biological systems for various applications. This includes the development of novel therapeutics, sustainable bio-manufacturing processes, and agricultural improvements. Gene synthesis companies stand to benefit from this growing demand by providing tailored solutions to researchers and industries seeking to leverage synthetic biology for innovation and problem-solving. The flexibility and scalability of gene synthesis technologies position market players to capitalize on the expanding landscape of synthetic biology applications, driving further growth and opportunity in the gene synthesis market.

Restraints/Challenges

• High Competition within the Medical Technology Industry Limits the Adoption of Gene Synthesis Technology

As medical technology companies compete for market share and innovation, they may prioritize investment in other areas over gene synthesis research and development. This intense competition can limit the resources available to gene synthesis companies, hindering their ability to innovate, expand, and differentiate their offerings. Established players in the medical technology sector may have existing relationships and market dominance, making it challenging for gene synthesis companies to penetrate the market and gain traction. The gene synthesis market may face obstacles in achieving widespread adoption and growth amidst the competitive landscape of the medical technology industry.

• Complexity Technical Challenges Inherent in Gene Synthesis results in Achieving High-Quality

Despite advancements, issues such as error rates, sequence fidelity, and scalability persist, posing hurdles to widespread adoption. Achieving high-quality synthesized DNA sequences, especially for longer or complex sequences, requires sophisticated synthesis platforms and expertise, which may limit accessibility for smaller research institutions or companies. The need for stringent quality control measures to ensure accuracy and reliability further adds to the complexity and cost of gene synthesis services, hindering market growth and adoption in certain contexts.

This market report provides details of new recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on the market contact Data Bridge Market Research for an Analyst Brief, our team will help you take an informed market decision to achieve market growth.

Recent Developments

• In 2023, Twist Bioscience and Astellas initiated a collaborative effort in multitarget antibody discovery research, leveraging Twist's synthetic DNA technology to advance antibody development for therapeutic applications
• In 2022, GenScript collaborated with Avectas to enhance nonviral cell therapy manufacturing processes, aiming to streamline and improve the efficiency of cell therapy production, potentially leading to advancements in personalized medicine
• In 2020, Twist Bioscience expanded its product portfolio by introducing clonalready gene fragments, offering researchers versatile tools for gene cloning and expression studies. This innovation enhances efficiency in protein expression pathways, enzyme engineering, and gene expression research. Additionally, a study published in an ACS journal highlighted the pressing need for improved cancer coverage worldwide, with millions of new cases and deaths underscoring the urgency for enhanced cancer detection and treatment initiatives

Gene Synthesis Market Scope

The market is segmented into component, gene type, gene synthesis type, application, method, end user, and distribution channel. The growth amongst these segments will help you analyze meager growth segments in the industries and provide the users with a valuable market overview and market insights to make strategic decisions to identify core market applications.

Component

• Synthesizers
• Consumables
• Software and Services

Gene Type

• Standard Gene
• Express Gene
• Complex Gene
• Others

Gene Synthesis Type

• Gene Library Synthesis
• Custom gene Synthesis

Application

• Synthetic Biology
• Genetic Engineering,
• Vaccine Design
• Therapeutics Antibodies
• Others

Method

• Solid Based Synthesis
• Chip-Based DNA Synthesis
• PCR-Based Enzyme Synthesis

End User

• Academic and Research Institutes
• Diagnostics Laboratories
• Biotech and Pharmaceutical Companies
• Others

Distribution Channel

• Direct Tender
• Online Distribution
• Third party Distributors

Gene Synthesis Market Regional Analysis/Insights

The market is analyzed, and market size insights and trends are provided by the country, component, gene type, gene synthesis type, application, method, end user, and distribution channel, as referenced above.

The countries covered in the market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

North America dominates the gene synthesis market, both in terms of market share and revenue, a trend expected to persist into the foreseeable future. This dominance is fueled by a growing demand for robust verification and validation processes within gene synthesis, particularly within the region's thriving research and development landscape. The emphasis on stringent quality control measures and the rapid pace of scientific advancement further bolster the market's growth trajectory in North America.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as down-stream and upstream value chain analysis, technical trends and porter's five forces analysis, case studies are some of the pointers used to forecast the market scenario for individual countries. Also, the presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.

Healthcare Infrastructure Growth Installed base and New Technology Penetration

The market also provides you with detailed market analysis for every country growth in healthcare expenditure for capital equipment, installed base of different kind of products for market, impact of technology using life line curves and changes in healthcare regulatory scenarios and their impact on the market. The data is available for historic period 2016-2021.

Competitive Landscape and Gene Synthesis Market Analysis

The market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies' focus related to market.

Some of the major players operating in the market are:

• ATDBio Ltd (U.K.)
• General Biosystems, Inc.  (U.S.)
• MACROGEN CO., LTD.  (South Korea)
• Boster Biological Technology  (U.S.)
• Creative Biogene  (U.S.)
• Bioneer Pacific  (South Korea)
• exonbio  (U.S.)
• trenzyme GmbH  (Germany)
• Twist Bioscience  (U.S.)
• BioCat GmbH (Germany)
• OriGene Technologies, Inc.  (U.S.)
• Integrated DNA Technologies, Inc. (U.S.)
• Eurofins Scientific  (Luxembourg)
• NZYTech (Portugal)
• Ansa Biotechnologies (U.S.)
• Thermo Fisher Scientific  Inc. (U.S.)
• Genescript  (U.S.)
• Synbio Technologies  (U.S.)
• Proteogenix  (France)
• Bio Basic Inc.  (Canada)
• ATG:biosynthetics GmbH  (Germany)
• Merck KGaA  (Germany)
• Kaneka Eurogentec S.A  (Belgium)
• Ginkgo Bioworks  (U.S.)
• Evonetix  (U.K.)
• ProMab (U.S.)
• GCC Biotech (INDIA) Pvt. Ltd.  (India)
• CSBio  (U.S.)
• Azenta US, Inc.  (U.S.)