Asia-Pacific Oligonucleotides Synthesis Market – Industry Trends and Forecast to 2031

Asia-Pacific Oligonucleotides Synthesis Market Analysis and Size

In therapeutics, the application of oligonucleotide synthesis is transformative. Antisense oligonucleotides (ASOs), small interfering RNA (siRNA), and aptamers are crafted through this process, serving as powerful tools in combating various diseases. ASOs regulate gene expression by targeting mRNA, offering promising treatments for genetic disorders, cancer, and viral infections. siRNA molecules silence specific genes, providing a targeted approach for diseases with a known genetic basis. The oligonucleotide synthesis market enables the development of these innovative therapeutics, driving advancements in precision medicine and personalized treatment approaches.

In December 2023, Moderna Therapeutics launched a groundbreaking oligonucleotide synthesis technology, revolutionizing mRNA-based therapeutics production. This proprietary platform enhances efficiency and scalability, facilitating rapid and cost-effective manufacturing of mRNA vaccines and therapies, marking a significant milestone in nucleic acid-based medicine development.

Asia-Pacific oligonucleotides synthesis market size was valued at USD 2.41 billion in 2023 and is projected to reach USD 8.75 billion by 2031, with a CAGR of 17.5% during the forecast period of 2024 to 2031. In addition to the insights on market scenarios such as market value, growth rate, segmentation, geographical coverage, and major players, the market reports curated by the Data Bridge Market Research also include depth expert analysis, patient epidemiology, pipeline analysis, pricing analysis, and regulatory framework.

Report Scope and Market Segmentation       

Market Definition

Oligonucleotide synthesis is a laboratory technique for manufacturing short sequences of nucleic acids, typically DNA or RNA molecules. It involves the step-by-step assembly of nucleotides using chemical reactions to form specific sequences. This process is crucial in various fields, including molecular biology, genetic engineering, and medical research, where custom-designed oligonucleotides are utilized for applications such as PCR, gene editing, and diagnostic testing.

Oligonucleotides Synthesis Market Dynamics

Drivers

• Demand for High-Quality Synthesis Increases due to Growing Advancements in Molecular Biology

As understanding of genetics and cellular processes deepens, the demand for custom-designed oligonucleotides increases. Techniques such as CRISPR-Cas9 gene editing, RNA interference (RNAi), and next-generation sequencing (NGS) rely heavily on oligonucleotides for precise targeting and manipulation of genes. Moreover, the emergence of synthetic biology and the quest for personalized medicine further amplify the need for tailored oligonucleotides. Consequently, the market witnesses heightened demand for high-quality synthesis services and products to support these cutting-edge research and therapeutic endeavors.

In June 2023, Illumina launched advanced CRISPR-Cas9 genome editing tools, boosting demand for custom oligonucleotides tailored for precise genetic manipulation. This development highlights the crucial role of oligonucleotide synthesis in driving cutting-edge molecular biology research and therapeutic innovation, contributing to the growth of the oligonucleotide synthesis market.

• Increasing Demand for Custom-Designed Oligonucleotides due to Investments in Pharmaceutical Research and Development

As pharmaceutical companies allocate more resources towards research and development (R&D), there is a growing demand for custom-designed oligonucleotides to support drug discovery and development efforts. Oligonucleotides are vital tools in various stages of the drug development process, from target identification and validation to preclinical and clinical studies. This surge in investment underscores the pivotal role of oligonucleotide synthesis in advancing the pharmaceutical industry's quest for innovative and effective therapeutics.

Opportunities

• Expanding Applications of Oligonucleotides in Diagnostics

Oligonucleotides serve as essential components in molecular diagnostic assays, enabling the detection of diseases with high accuracy and specificity. They are utilized in techniques such as polymerase chain reaction (PCR), nucleic acid hybridization, and next-generation sequencing (NGS) for identifying genetic mutations, pathogens, and biomarkers associated with various diseases. The increasing demand for precise and reliable diagnostic tests, coupled with advancements in genomic medicine, drives the need for custom-designed oligonucleotides tailored to specific diagnostic applications.

For instance, In September 2023, Roche Diagnostics launched a molecular diagnostic assay utilizing oligonucleotide probes for detecting SARS-CoV-2 variants. This assay enables rapid and accurate identification of emerging virus strains, aiding healthcare professionals in monitoring and responding to changes in the viral landscape. This development highlights the crucial role of oligonucleotide synthesis in enhancing diagnostic capabilities for infectious diseases.

• Rapid Growth in Genetic Engineering Increases the Adoption of Oligonucleotide Synthesis

Genetic engineering techniques, such as CRISPR-Cas9, TALENs, and zinc-finger nucleases, require precise and customizable oligonucleotides for gene editing, gene regulation, and gene therapy applications. As research in genetic engineering expands across academic, industrial, and clinical settings, the demand for high-quality, synthesized oligonucleotides increases substantially. Oligonucleotides serve as essential tools in designing gene editing constructs, gene knockouts, and gene knock-ins, facilitating advancements in agriculture, biotechnology, and medicine. This growth trajectory underscores the pivotal role of oligonucleotide synthesis in supporting and driving innovation in genetic engineering endeavors.

Restraints/Challenges

• High Production Costs limits the Accessibility of Oligonucleotide-Based Products

High costs pose a significant restraint on the oligonucleotide synthesis market. The complex nature of oligonucleotide synthesis processes, coupled with the need for specialized equipment and reagents, contributes to elevated production expenses. High production costs limit the accessibility of oligonucleotide-based products to smaller research laboratories and academic institutions with limited budgets. Moreover, the pricing dynamics may deter potential customers, impacting market growth and adoption rates.

• Increasing Regulatory Challenges Complicate the Expansion of Oligonucleotide Synthesis Companies

Stringent regulatory requirements governing the development, manufacturing, and commercialization of oligonucleotide-based products, particularly therapeutics and diagnostics, can significantly prolong the time-to-market and increase costs. Regulatory agencies often demand extensive preclinical and clinical data to demonstrate safety, efficacy, and quality, adding complexity and uncertainty to the approval process. Evolving regulatory landscapes and varying requirements across different regions and jurisdictions further complicate market entry and expansion efforts for oligonucleotide synthesis companies.

This market report provides details of new recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on the market contact Data Bridge Market Research for an Analyst Brief, our team will help you take an informed market decision to achieve market growth.

Recent Developments

• In October 2023, IDT launched a new therapeutic manufacturing facility, equipped to produce therapeutic oligonucleotides, meeting the increasing demand in genomic medicine and personalized treatments
• In September 2023, Danaher's IDT launched xGen NGS products tailored for the Ultima Genomics UG 100TM platform, including adapters, primers, and universal blockers, enhancing versatility in DNA, RNA, & methylation sequencing workflows
• In July 2023, Analytix launhced wavePREP and Xelsius instruments, catering to organic synthesis needs, with wavePREP focusing on oligonucleotide synthesis and Xelsius offering multireaction synthesis capabilities
• In July 2022, WuXi STA expanded its oligonucleotide and peptide manufacturing capacity with a new facility in Changzhou, addressing the growing demand for therapeutic development worldwide
• In April 2022, Bachem collaborated with Eli Lilly to advance oligonucleotide-based active pharmaceutical ingredients, leveraging Bachem's expertise and infrastructure to implement Lilly's innovative manufacturing technology

Oligonucleotides Synthesis Market Scope

The market is segmented on the basis of product type, application and end-user. The growth amongst these segments will help you analyze meagre growth segments in the industries and provide the users with a valuable market overview and market insights to help them make strategic decisions for identifying core market applications.

Product Type

• Synthesized Oligonucleotide Products
• Reagents
• Equipment
• Services

Application

• Research
• Therapeutics
• Diagnostics

End User

• Academic Research Institutes
• Pharmaceutical and Biotechnology Companies
• Hospital and Diagnostic Laboratories

Asia-Pacific Oligonucleotides Synthesis Market Regional Analysis/Insights

The market is analysed and market size insights and trends are provided by country, type, application, and end user as referenced above.

The countries covered in the market report are Japan, China, India, South Korea, Australia, Singapore, Thailand, Malaysia, Indonesia, Philippines, Vietnam and rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC)

China is expected to dominate in the market due to its robust healthcare infrastructure and the significant presence of key industry players. Additionally, the surge in surgical procedures among athletes further propels market growth. Moreover, the increasing research endeavors in the region contribute to expanding applications and demand for oligonucleotides, solidifying China's position as a frontrunner in the market.

Japan is expected for substantial growth in the market, driven by government efforts to boost awareness and medical tourism. The region's burgeoning research endeavors, coupled with vast untapped markets and a sizable population, contribute to its promising healthcare landscape. Additionally, escalating demand for high-quality healthcare further fuels this growth trajectory, positioning Japan as a key player in the global healthcare industry.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as down-stream and upstream value chain analysis, technical trends and porter's five forces analysis, case studies are some of the pointers used to forecast the market scenario for individual countries. Also, the presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.

Healthcare Infrastructure Growth Installed base and New Technology Penetration

The market also provides you with detailed market analysis for every country growth in healthcare expenditure for capital equipment, installed base of different kind of products for market, impact of technology using life line curves and changes in healthcare regulatory scenarios and their impact on the market. The data is available for historic period 2016-2021.

Competitive Landscape and Oligonucleotides Synthesis Market Analysis

The market competitive landscape provides details of competitors. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width, and breadth, application dominance. The above data points provided are only related to the companies' focus related to the market.

Some of the major players operating in the market are:

• Thermo Fisher Scientific Inc. (U.S.)
• Merck KGaA (U.S.)
• GE Healthcare (U.S.)
• Agilent Technologies, Inc. (U.S.)
• Bio-Synthesis, Inc. (U.S.)
• Kaneka Eurogentec S.A (Belgium)
• Integrated DNA Technologies, Inc. (U.S.)
• Biolegio (Netherlands)
• Twist Bioscience (U.S.)
• Danaher Corporation (U.S.)
• LGC Biosearch Technologies (U.K.)
• Sarepta Therapeutics, Inc. (U.S.)
• Maravai LifeSciences (U.S.)
• Eurofins Scientific (Luxembourg)
• GenScript (U.S.)

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