Mercado global de reagentes e equipamentos de transfecção – Tendências do setor e previsão para 2030

Análise e insights de mercado de reagentes e equipamentos de transfecção

A transfecção envolve a introdução de ácido nucleico nas células eucarióticas por métodos virais e não virais. O método de transfecção pode superar o desafio de transferir a membrana carregada negativamente. Produtos químicos como o fosfato de cálcio e o dietilaminoetil (DEAE)-dextrano ou reagente catiónico à base de lípidos reagem com a camada exterior de ADN. Neutraliza a carga negativa global, transmite a quantidade positiva à molécula e, portanto, permite a entrega do ADN. Métodos físicos como a eletroporação criam poros minúsculos na membrana celular através da aplicação de voltagem elétrica, permitindo a entrada do ADN diretamente no citoplasma. O DEAE-dextrano é utilizado para transfecção transitória; no entanto, a lipofecção pode atingir uma transfecção estável e, por isso, pode ser utilizada para a expressão proteica a longo prazo. A transfecção mediada por fosfato de cálcio também pode ser utilizada para a transfecção estável. O método de transfecção viral atinge uma elevada eficiência e é utilizado em diversas fases do desenvolvimento de produtos farmacêuticos.

O método de transfecção é utilizado para diversas aplicações que envolvem a agricultura para a proteção das culturas e aumento do rendimento, para a produção de produtos de biologia sintética para realçar sabores e fragrâncias e para melhorar proteínas unicelulares, entre outras. A procura de transfecção aumentou tanto nos países desenvolvidos como nos países em desenvolvimento, e a razão por detrás disto é a ocorrência crescente de doenças crónicas. O mercado da transfecção está a crescer devido à crescente procura de genes quiméricos e à utilização de biofármacos na produção de proteínas. O mercado crescerá no período de previsão devido à exploração dos mercados emergentes, às iniciativas estratégicas dos participantes do mercado e ao aumento do apoio governamental.

Espera-se que o elevado custo dos instrumentos, a eficácia seletiva do reagente de transfeção e os danos celulares induzidos pelos métodos de transfeção restrinjam o crescimento global do mercado de reagentes e equipamentos de transfeção.

O mercado está a crescer devido a diversas iniciativas estratégicas adotadas pelos players do mercado que envolvem aquisição, colaboração e parceria.

A Data Bridge Market Research analisa que o mercado global de reagentes e equipamentos de transfecção deverá atingir o valor de 2.284.494,00 mil dólares até 2030, com um CAGR de 9,6% no período de previsão.

Definição de mercado

The transfection method is used to introduce RNA, DNA or protein products in cells to alter the phenotype and genotype of the organism. The transfection method involves the new gene transfer or transferring a gene construct such as Clustered regularly interspaced short palindromic repeats (CRISPR) for genome editing purposes. Transfection has wide applications in the field of immunotherapy, gene therapy, and cell therapy, among others. Transfection involves both non-viral and viral-mediated transfection. The chemical and physical methods can achieve non–viral transfection. The most common chemical method used for transfection is calcium phosphate transfection, and liposome transfection, among others. Viral transfection yields high transfection efficiencies, and various types of physical methods employed for transfection include microinjection, biolistic particle delivery, and electroporation, among which electroporation provides high transfection efficiency. Transfection is of two types either it can be transient or stable transfection. For short-term gene expression studies such as gene knock-out studies, small-scale production transient transfection method is preferred; however, long-term research studies and large-scale protein production stable transfection methods are widely adopted.

Global Transfection Reagent and Equipment Market Dynamics

This section deals with understanding the market drivers, advantages, opportunities, restraints, and challenges. All of this is discussed in detail below:    

Drivers

• RISE IN THE PREVALENCE OF CHRONIC DISEASES

The prevalence of chronic diseases is increasing worldwide, leading to the demand for effective and accurate treatment. Transfection is used to deliver targeted modified genes to treat several genetic diseases. The transfection method is also used for the delivery of the CRISPR gene, which can enhance adaptive immunity and prevent an individual from different diseases.

The increasing cases of chronic diseases such as COVID-19 and other infectious diseases have led to the discovery of effective gene therapy products which can replace the defective gene with the correct gene. The transfection method is widely used for gene therapy, among others. As the demand for effective and accurate treatment is increasing worldwide, the demand for gene therapy and transfection method is also increasing. Moreover, several undergoing researches proving gene therapy to have the potential for chronic disease treatment are also increasing its demand among physicians and patients. This thus signifies that the rise in chronic disease prevalence is acting as a driver for the global transfection Reagent and equipment market growth.

• DEVELOPMENT OF SYNTHETIC BIOLOGY PRODUCTS

Synthetic biology is a new era of biology that incorporates the engineering principle into biology. Synthetic biology involves the chemical synthesis of DNA by combining the knowledge of genomics to reassemble the DNA genomes. The synthetic biology that sequences into the new genes involves genetic engineering, which incorporates the transfection method, among others. As the demand for synthetic biology products is increasing worldwide, the use of transfection products is also increasing.

The demand for synthetic biology products is increasing due to the increasing demand for effective and innovative products. The manufacturing of synthetic products enhances the demand for transfection products, as gene transfer can be accompanied by the transfection method, among others. Thus, this signifies that synthetic product development drives the global transfection Reagent and equipment market growth.

Restraint

• CELL DAMAGE INDUCED BY TRANSFECTION PROCEDURE

Some transfection methods have been reported to cause cell damage, reducing the reproducibility of the overall method. Among the several kinds of transfection procedures, electroporation has been reported to cause maximum cell damage as per the increase in voltage. This cell damage lowers the efficiency rate and impacts the ongoing project.

One of the most common side effects of the transfection procedure is cell damage which lowers the cells metabolic events and leads to cell death. This damaged cell can enhance the media toxicity and hence produces inappropriate results. Thus, this suggests that cell damage induced by the transfection procedure acts as a restraint for the global transfection Reagent and equipment market growth.

Opportunity

• EXPLORATION OF EMERGING MARKET

The transfection products have been shown as promising tools for the genetic engineering and proteomic industry. The top market for transfection products is in Europe and North America. By looking at the positive outcomes of these products, many market players are penetrating their roots in growing economies involving China and India, among others. The emerging market allows these market players to combat the loss that arises from the well-established market.

As emerging markets allow the market players to overcome the economic downturn specified to particular established markets, investment and exploration of emerging markets allow the market players to engage in the development and manufacturing of transfection products to attain lucrative growth. Thus, this signifies that exploring emerging markets is an opportunity to grow the global transfection Reagent and equipment market.

Challenge

• LONG APPROVAL PROCEDURE

The long approval procedure for transfection Reagent and instruments is a hindering agent for the growth of the transfection market. Transfection products are subjected to extensive regulations and have to monitor every time. The transfection products are widely used for the insertion of desired gene molecules in a particular cell line to obtain proteins and other biological compounds. This process is thus investigated and approved by the long and strict regulatory procedures. The long process required to get a positive result from every conducted clinical trial led to more time consumption and the investment of lots of money by market players.

The transfection Reagent are mostly subjected to 21CFR parts 210 and 211 U.S. FDA guidelines, according to which the manufacturers had to assure that the reagent manufactured meets the safety, packaging and processing characteristics proposed by the regulatory agencies. The owner or manufacturer has to submit licenses under section 351 of the PHS (Public Health Services) Act, which is quite a tedious procedure. Thus, this signifies that long approval procedures challenge the global transfection Reagent and equipment market growth.

Recent Developments

• In August 2021, Mirus Bio expanded the TransIT VirusGen platform for Good Manufacturing Practice (GMP) viral vector production to support cell and gene therapy development, process operations, and commercial production. The extension, referred to as TransIT VirusGen GMP Transfection Reagent, is designed to improve the packaging and delivery of vector DNA to suspension and adherent HEK 293 cell types to improve the production of recombinant adeno-associated viruses and lentiviral vectors.
• In April 2021, BOC Sciences announced the launch of two in vivo RNA transfection kits, namely siRNA in vivo transfection kits and mRNA in vivo transfection kits, suitable for in vivo transfection of siRNA and mRNA, respectively.

Global Transfection Reagent and Equipment Market Scope

Global transfection Reagent and equipment market is segmented into nine notable segments such as products, stage, methods, type, types of molecule, application, end user, organism, and distribution channel. The growth among segments helps you analyze niche pockets of growth and strategies to approach the market and determine your core application areas and the difference in your target markets.  

PRODUCTS

• INSTRUMENTS
• REAGENT & KITS

On the basis of products, the global transfection reagent and equipment market is segmented into instruments and reagent & kits.

STAGE

• RESEARCH
• PRECLINICAL
• CLINICAL PHASES
• COMMERCIAL

On the basis of stage, the global transfection reagent and equipment market is segmented into research, preclinical, clinical phases and commercial.

TYPE

• TRANSIENT TRANSFECTION REAGENT AND EQUIPMENT
• STABLE TRANSFECTION REAGENT AND EQUIPMENT

On the basis of type, the global transfection reagent and equipment market is segmented into transient transfection reagent and equipment and stable transfection reagent and equipment.

METHODS

• NON-VIRAL METHODS
• VIRAL METHODS

On the basis of methods, the global transfection reagent and equipment market is segmented into non-viral methods and viral methods.

TYPES OF MOLECULE

• PLASMID DNA
• DNA OLIGONUCLEOTIDES
• SMALL INTERFERING RNA (SIRNA)
• PROTEINS
• RIBONUCLEOPROTEIN COMPLEXES (RNPS)
• OTHERS

On the basis of types of molecule, the global transfection reagent and equipment market is segmented into plasmid DNA, DNA oligonucleotides, small interfering RNA (siRNA), proteins, ribonucleoprotein complexes (RNPs) and others.

ORGANISM

• BACTERIA
• MAMMALIAN CELLS
• FUNGI
• PLANTS
• VIRUS

On the basis of organism, the global transfection reagent and equipment market is segmented into bacteria, mammalian cells, fungi, plants and virus.

APPLICATION

• BY TYPE
  • IN VITRO APPLICATION
  • IN VIVO APPLICATION
  • BIOPRODUCTION
  • OTHERS
• BY INDUSTRY
  • AGRICULTURE
  • SYNTHETIC BIOLOGY
  • OTHERS

On the basis of application, the global transfection reagent and equipment market is segmented by type into in vitro application, in vivo application, bioproduction, others and by industry into agriculture, synthetic biology, others.

END USER

• BIOPHARMA
• CROS
• CMOS/CDMOS
• ACADEMIA
• HOSPITALS
• CLINICAL LABS
• OTHERS

On the basis of end user, the global transfection reagent and equipment market is segmented into biopharma, CROs, CMOs/ CDMOs, academia, hospitals, clinical labs and others.

DISTRIBUTION CHANNEL

• DIRECT TENDER
• RETAIL SALES
• OTHERS

On the basis of distribution channel, the global transfection Reagent and equipment market is segmented into direct tender, retail sales and others.

Global Transfection Reagent and Equipment Market Regional Analysis/Insights

The global transfection reagent and equipment market is categorized into many notable segments such as geography, products, stages, methods, type, types of molecule, application, end user, organism, and distribution channel.

The countries covered in this market report are U.S., Canada, Mexico, Germany, France, Italy, U.K., Spain, Switzerland, Russia, Netherlands, Belgium, Turkey, and Rest of Europe, China, Japan, India, Australia, South Korea, Singapore, Thailand, Malaysia, Philippines, Indonesia, and Rest of Asia-Pacific, Brazil, Argentina, Rest of South America, South Africa, Saudi Arabia, UAE, Israel, Egypt, and Rest of the Middle East and Africa.

In 2023, the North America region is dominating due to the presence of key market players in the largest consumer market with high GDP. U.S is expected to grow due to rise in the prevalence of chronic and rare diseases leading to increase in the use of transfection reagent and equipment.

A América do Norte está a dominar o mercado devido ao aumento do investimento em cuidados de saúde que deverá impulsionar o crescimento do mercado. Os EUA dominam a região da América do Norte devido à forte presença de atores importantes. A Alemanha domina a região da Europa devido à crescente procura por parte dos mercados emergentes e à expansão. A China domina a região Ásia-Pacífico devido à crescente inclinação dos clientes para processos tecnológicos avançados.

A secção do país do relatório também fornece fatores individuais de impacto no mercado e alterações na regulamentação do mercado interno que impactam as tendências atuais e futuras do mercado. Dados como novas vendas, vendas de reposição, demografia do país, atos regulamentares e tarifas de importação e exportação são alguns dos principais indicadores utilizados para prever o cenário de mercado para países individuais. Além disso, são considerados a presença e disponibilidade de marcas globais e os desafios enfrentados devido à concorrência grande ou escassa de marcas locais e nacionais, e o impacto dos canais de vendas, ao mesmo tempo que se fornece uma análise de previsão dos dados do país .

Cenário competitivo e análise global da quota de mercado de reagentes e equipamentos de transfecção

O panorama competitivo do mercado global de reagentes e equipamentos de transfecção fornece detalhes por concorrente. Os detalhes incluídos são a visão geral da empresa, finanças da empresa, receitas geradas, potencial de mercado, investimento em I&D, novas iniciativas de mercado, localizações e instalações de produção, pontos fortes e fracos da empresa, lançamento de produtos, aprovações de produtos, largura e fôlego do produto, domínio de aplicação, tipo de produto linha de vida curva. Os dados acima fornecidos estão apenas relacionados com o foco da empresa no mercado global de reagentes e equipamentos de transfecção.

Alguns dos principais players que operam neste mercado são a Mirus Bio LLC., Promega Corporation, Polyplus Transfection, Bio-Rad Laboratories, Inc., Merck KGaA, Lonza, MaxCyte, Inc., Altogen Biosystems, SBS Genetech, FUJIFILM Irvine Scientific (A Subsidiária da FUJIFILM Holdings Corporation), Avanti Polar Lipids (uma subsidiária da Croda International Plc), PerkinElmer chemagen Technologie GmbH (uma subsidiária da PerkinElmer Inc.), Cytiva, Geno Technology Inc., EUA, R&D Systems, Inc., Takara Bio Inc. ., Thermofisher Scientific Inc., Roche Molecular Systems, Inc. (uma subsidiária da F. Hoffmann-La Roche Ltd), QIAGEN, OriGene Technologies, Inc., Applied Biological Materials Inc. Subsidiária da Danaher), Amyris, Codexis, Autolus, SignaGen Laboratories, Impossible Foods Inc., Genlantis Inc., Ginkgo Bioworks, Verve Therapeutics, Inc., Conagen, Inc., Poseida Therapeutics, Inc., e Twist Bioscience, entre outras.

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