亚太转染试剂和设备市场 – 行业趋势和 2030 年预测

亚太地区转染试剂和设备市场分析与洞察

转染涉及通过病毒和非病毒方法将核酸引入真核细胞。转染方法可以克服转移带负电荷的膜的挑战。磷酸钙和二乙氨基乙基 (DEAE) 葡聚糖或阳离子脂质基试剂等化学物质与外部 DNA 外壳发生反应。它中和了整体负电荷，将正电荷赋予分子，从而允许 DNA 传递。电穿孔等物理方法通过施加电压在细胞膜上产生微小孔隙，允许 DNA 直接进入细胞质。DEAE-葡聚糖用于瞬时转染；然而，脂质转染可以实现稳定转染，因此可用于长期蛋白质表达。磷酸钙介导的转染也可用于稳定转染。病毒转染方法效率高，可用于药品开发的多个阶段。

转染方法用于农业的多种应用，包括保护作物和提高产量、生产合成生物产品以增强风味和香味、以及增强单细胞蛋白等。发达国家和发展中国家对转染的需求都在增加，其背后的原因是慢性病发病率的增加。由于对嵌合基因的需求不断增长以及生物制药在蛋白质生产中的利用，转染市场正在增长。由于新兴市场的探索、市场参与者的战略举措以及政府支持的增加，市场将在预测期内增长。

仪器的高成本、转染试剂的选择性有效性以及转染方法引起的细胞损伤预计会抑制亚太地区转染试剂和设备市场的增长。

The market is growing due to several strategic initiatives adopted by market players involving acquisition, collaboration, and partnership.

Data Bridge Market Research analyzes that the Asia-Pacific transfection reagent and equipment market is expected to reach the value of USD 358,284.09 thousand by 2030, at a CAGR of 10.7% during the forecast period.

Market Definition

The transfection method is used to introduce RNA, DNA or protein products in cells to alter the phenotype and genotype of the organism. The transfection method involves the new gene transfer or transferring a gene construct such as Clustered regularly interspaced short palindromic repeats (CRISPR) for genome editing purposes. Transfection has wide applications in the field of immunotherapy, gene therapy, and cell therapy, among others. Transfection involves both non-viral and viral-mediated transfection. The chemical and physical methods can achieve non–viral transfection. The most common chemical method used for transfection is calcium phosphate transfection, and liposome transfection, among others. Viral transfection yields high transfection efficiencies, and various types of physical methods employed for transfection include microinjection, biolistic particle delivery, and electroporation, among which electroporation provides high transfection efficiency. Transfection is of two types either it can be transient or stable transfection. For short-term gene expression studies such as gene knock-out studies, small-scale production transient transfection method is preferred; however, long-term research studies and large-scale protein production stable transfection methods are widely adopted.

Asia-Pacific Transfection Reagent and Equipment Market Dynamics

This section deals with understanding the market drivers, advantages, opportunities, restraints, and challenges. All of this is discussed in detail below:    

Drivers

• RISE IN THE PREVALENCE OF CHRONIC DISEASES

The prevalence of chronic diseases is increasing worldwide, leading to the demand for effective and accurate treatment. Transfection is used to deliver targeted modified genes to treat several genetic diseases. The transfection method is also used for the delivery of the CRISPR gene, which can enhance adaptive immunity and prevent an individual from different diseases.

The increasing cases of chronic diseases such as COVID-19 and other infectious diseases have led to the discovery of effective gene therapy products which can replace the defective gene with the correct gene. The transfection method is widely used for gene therapy, among others. As the demand for effective and accurate treatment is increasing worldwide, the demand for gene therapy and transfection method is also increasing. Moreover, several undergoing researches proving gene therapy to have the potential for chronic disease treatment are also increasing its demand among physicians and patients. This thus signifies that the rise in chronic disease prevalence is acting as a driver for the Asia-Pacific transfection Reagent and equipment market growth.

• DEVELOPMENT OF SYNTHETIC BIOLOGY PRODUCTS

Synthetic biology is a new era of biology that incorporates the engineering principle into biology. Synthetic biology involves the chemical synthesis of DNA by combining the knowledge of genomics to reassemble the DNA genomes. The synthetic biology that sequences into the new genes involves genetic engineering, which incorporates the transfection method, among others. As the demand for synthetic biology products is increasing worldwide, the use of transfection products is also increasing.

The demand for synthetic biology products is increasing due to the increasing demand for effective and innovative products. The manufacturing of synthetic products enhances the demand for transfection products, as gene transfer can be accompanied by the transfection method, among others. Thus, this signifies that synthetic product development drives the Asia-Pacific transfection Reagent and equipment market growth.

Restraint

• CELL DAMAGE INDUCED BY TRANSFECTION PROCEDURE

Some transfection methods have been reported to cause cell damage, reducing the reproducibility of the overall method. Among the several kinds of transfection procedures, electroporation has been reported to cause maximum cell damage as per the increase in voltage. This cell damage lowers the efficiency rate and impacts the ongoing project.

One of the most common side effects of the transfection procedure is cell damage which lowers the cells metabolic events and leads to cell death. This damaged cell can enhance the media toxicity and hence produces inappropriate results. Thus, this suggests that cell damage induced by the transfection procedure acts as a restraint for the Asia-Pacific transfection Reagent and equipment market growth.

Opportunity

• EXPLORATION OF EMERGING MARKET

The transfection products have been shown as promising tools for the genetic engineering and proteomic industry. The top market for transfection products is in Europe and North America. By looking at the positive outcomes of these products, many market players are penetrating their roots in growing economies involving China and India, among others. The emerging market allows these market players to combat the loss that arises from the well-established market.

As emerging markets allow the market players to overcome the economic downturn specified to particular established markets, investment and exploration of emerging markets allow the market players to engage in the development and manufacturing of transfection products to attain lucrative growth. Thus, this signifies that exploring emerging markets is an opportunity to grow the Asia-Pacific transfection Reagent and equipment market.

Challenge

• LONG APPROVAL PROCEDURE

The long approval procedure for transfection Reagent and instruments is a hindering agent for the growth of the transfection market. Transfection products are subjected to extensive regulations and have to monitor every time. The transfection products are widely used for the insertion of desired gene molecules in a particular cell line to obtain proteins and other biological compounds. This process is thus investigated and approved by the long and strict regulatory procedures. The long process required to get a positive result from every conducted clinical trial led to more time consumption and the investment of lots of money by market players.

The transfection Reagent are mostly subjected to 21CFR parts 210 and 211 U.S. FDA guidelines, according to which the manufacturers had to assure that the reagent manufactured meets the safety, packaging and processing characteristics proposed by the regulatory agencies. The owner or manufacturer has to submit licenses under section 351 of the PHS (Public Health Services) Act, which is quite a tedious procedure. Thus, this signifies that long approval procedures challenge the Asia-Pacific transfection Reagent and equipment market growth.

Recent Developments

• In August 2021, Mirus Bio expanded the TransIT VirusGen platform for Good Manufacturing Practice (GMP) viral vector production to support cell and gene therapy development, process operations, and commercial production. The extension, referred to as TransIT VirusGen GMP Transfection Reagent, is designed to improve the packaging and delivery of vector DNA to suspension and adherent HEK 293 cell types to improve the production of recombinant adeno-associated viruses and lentiviral vectors.
• In April 2021, BOC Sciences announced the launch of two in vivo RNA transfection kits, namely siRNA in vivo transfection kits and mRNA in vivo transfection kits, suitable for in vivo transfection of siRNA and mRNA, respectively.

Asia-Pacific Transfection Reagent and Equipment Market Scope

Asia-Pacific transfection Reagent and equipment market is segmented into nine notable segments such as products, stage, methods, type, types of molecule, application, end user, organism, and distribution channel. The growth among segments helps you analyze niche pockets of growth and strategies to approach the market and determine your core application areas and the difference in your target markets.  

PRODUCTS

• INSTRUMENTS
• REAGENT & KITS

On the basis of products, the Asia-Pacific transfection reagent and equipment market is segmented into instruments and reagent & kits.

STAGE

• RESEARCH
• PRECLINICAL
• CLINICAL PHASES
• COMMERCIAL

On the basis of stage, the Asia-Pacific transfection reagent and equipment market is segmented into research, preclinical, clinical phases and commercial.

TYPE

• TRANSIENT TRANSFECTION REAGENT AND EQUIPMENT
• STABLE TRANSFECTION REAGENT AND EQUIPMENT

On the basis of type, the Asia-Pacific transfection reagent and equipment market is segmented into transient transfection reagent and equipment and stable transfection reagent and equipment.

METHODS

• NON-VIRAL METHODS
• VIRAL METHODS

On the basis of methods, the Asia-Pacific transfection reagent and equipment market is segmented into non-viral methods and viral methods.

TYPES OF MOLECULE

• PLASMID DNA
• DNA OLIGONUCLEOTIDES
• SMALL INTERFERING RNA (SIRNA)
• PROTEINS
• RIBONUCLEOPROTEIN COMPLEXES (RNPS)
• OTHERS

On the basis of types of molecule, the Asia-Pacific transfection reagent and equipment market is segmented into plasmid DNA, DNA oligonucleotides, small interfering RNA (siRNA), proteins, ribonucleoprotein complexes (RNPs) and others.

ORGANISM

• BACTERIA
• MAMMALIAN CELLS
• FUNGI
• PLANTS
• VIRUS

On the basis of organism, the Asia-Pacific transfection reagent and equipment market is segmented into bacteria, mammalian cells, fungi, plants and virus.

APPLICATION

• BY TYPE
  • IN VITRO APPLICATION
  • IN VIVO APPLICATION
  • BIOPRODUCTION
  • OTHERS
• BY INDUSTRY
  • AGRICULTURE
  • SYNTHETIC BIOLOGY
  • OTHERS

On the basis of application, the Asia-Pacific transfection reagent and equipment market is segmented by type into in vitro application, in vivo application, bioproduction, others and by industry into agriculture, synthetic biology, others.

END USER

• BIOPHARMA
• CROS
• CMOS/CDMOS
• ACADEMIA
• HOSPITALS
• CLINICAL LABS
• OTHERS

On the basis of end user, the Asia-Pacific transfection reagent and equipment market is segmented into biopharma, CROs, CMOs/ CDMOs, academia, hospitals, clinical labs and others.

DISTRIBUTION CHANNEL

• DIRECT TENDER
• RETAIL SALES
• OTHERS

On the basis of distribution channel, the Asia-Pacific transfection Reagent and equipment market is segmented into direct tender, retail sales and others.

Asia-Pacific Transfection Reagent and Equipment Market Regional Analysis/Insights

The Asia-Pacific transfection reagent and equipment market is categorized into many notable segments such as geography, products, stages, methods, type, types of molecule, application, end user, organism, and distribution channel.

The countries covered in this market report are China, Japan, India, Australia, South Korea, Singapore, Thailand, Malaysia, Philippines, Indonesia, and Rest of Asia-Pacific.

In 2023, China dominates Asia-Pacific region due to increasing customer inclinations towards advanced technological processes.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impact the current and future trends of the market. Data points such as new sales, replacement sales, country demographics, regulatory acts, and import-export tariffs are some of the major pointers used to forecast the market scenario for individual countries. Also, presence and availability of Asia-Pacific brands and their challenges faced due to large or scarce competition from local and domestic brands, and impact of sales channels are considered while providing forecast analysis of the country data.

竞争格局和亚太转染试剂和设备市场份额分析

亚太转染试剂和设备市场竞争格局按竞争对手提供详细信息。详细信息包括公司概况、公司财务状况、收入、市场潜力、研发投资、新市场计划、生产基地和设施、公司优势和劣势、产品发布、产品批准、产品宽度和广度、应用优势、产品类型生命线曲线。以上提供的数据点仅与公司对亚太转染试剂和设备市场的关注有关。

该市场的一些主要参与者包括 Mirus Bio LLC.、Promega Corporation、Polyplus Transfection、Bio-Rad Laboratories, Inc.、Merck KGaA、Lonza、MaxCyte, Inc.、Altogen Biosystems、SBS Genetech、FUJIFILM Irvine Scientific（FUJIFILM Holdings Corporation 的子公司）、Avanti Polar Lipids（Croda International Plc 的子公司）、PerkinElmer chemagen Technologie GmbH（PerkinElmer Inc. 的子公司）、Cytiva、Geno Technology Inc.、USA、R&D Systems, Inc.、Takara Bio Inc.、Thermofisher Scientific Inc.、Roche Molecular Systems, Inc.（F. Hoffmann-La Roche Ltd 的子公司）、QIAGEN、OriGene Technologies, Inc.、Applied Biological Materials Inc. (abm)、Beckman Coulter, Inc.（Danaher 的子公司）、Amyris、其中包括 Codexis、Autolus、SignaGen Laboratories、Impossible Foods Inc.、Genlantis Inc.、Ginkgo Bioworks、Verve Therapeutics, Inc.、Conagen, Inc.、Poseida Therapeutics, Inc. 和 Twist Bioscience 等。

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