In teeth, there is a molecular cold sensor that highly activates when our teeth come in contact with anything cold. This causes a problem of toothache which can be very harmful and painful as well which gets annoying sometimes. An ion channel called TRPC5 acts as a molecular cold sensor which is mentioned above. Due to this toothache, a person is prescribed to avoid certain food items and for people with tooth decay, drinking a cold beverage can be agony and could lead to sensitiveness. It is analyzed and recorded by people that this is a very unique kind of pain and it is also said by David Clapham who is a vice president and chief scientific officer of the Howard Hughes Medical Institute. It is just excruciating. After all of these statements, the root cause behind this has been figured out because it is a common problem nowadays. Though, it is very difficult to get rid of it because this problem doesn’t have any 100% accurate solutions for it.
There were lots of experienced and educated scientists who researched this. Now his team pinpointed and located the molecular and cellular players involved. In both mice and humans, tooth cells which are called odontoblasts contain cold-sensitive proteins that can detect temperature drops; the team reported it in the journal science advance. The signals conveyed and received from these cells can enhance a jolt of pain to the brain and through this pain; it is tough to calculate the results.
These works have some real possibilities which can offer great outcomes and it also explains how one age-old home remedy eases toothaches and how an individual gets relief from it. One of the main ingredients to cure this is clove oil which has been used for decades to achieve a proper and relevant solution for the problem. In clove oil, there is a chemical that has the potential to block the cold sensor proteins says an electrophysiologist, named, Katharina Zimmermann who led the work at Friedrich Alexander University Erlangen Nurnberg, located in Germany.
